Sökning: "Complement System Proteins"
Visar resultat 1 - 5 av 103 avhandlingar innehållade orden Complement System Proteins.
1. Rules of engagement - Regulation of complement response in tissue
Sammanfattning : Always in motion and probing for danger, complement proteins are found in every space and notch of the body. Their omnipresence combined with an ability to wreak havoc when activated, mandates a strong leash! The how, when, and where to unleash or constrain the complement response remain partly answered questions, despite the significant progress made in the field in the past 100 years. LÄS MER
2. Crosstalk Between Activated Platelets and the Complement System
Sammanfattning : Several studies have shown that complement and thrombotic events co-exist. Platelets have been suspected to act as the bridge between the two cascade systems. LÄS MER
3. Complement aberrations and autoantibodies to complement proteins in relation to disease mechanisms
Sammanfattning : The complement system, a part of the innate immune system with several links to the adaptive immune system, plays an important role in the pathogenesis of many diseases. The purpose of this thesis was to document and clarify some of these mechanisms. The thesis is based on four papers (I-IV). LÄS MER
4. Modern roles for an ancient system. Intracellular Complement in the regulation of β cell function
Sammanfattning : Type 2 diabetes (T2D) is characterised by defective insulin exocytosis from the pancreatic β cells, accompanied by insulin resistance. Reduced β cells mass is often seen in T2D individuals, caused by enhanced β cells apoptosis. It is now understood that several components drive β cells dysfunction and apoptosis. LÄS MER
5. Synaptic elimination and the complement system in Alzhaimer's disease
Sammanfattning : The mechanisms behind Alzheimer’s disease (AD) are largely unknown. The disease is to a large extent hereditary, and the best pathophysiological correlate to the severity of the symptoms is loss of synapses. LÄS MER