Sökning: "platelet microparticles"

Visar resultat 1 - 5 av 22 avhandlingar innehållade orden platelet microparticles.

  1. 1. Tissue Factor Biological Functions Coagulation Activity in Microparticles and Signaling with Focus On Migration and Apoptosis

    Detta är en avhandling från Uppsala : Universitetsbiblioteket

    Författare :Mikael Åberg; Agneta Siegbahn; Carl-Henrik Heldin; Teet Velling; Björn Dahlbäck; [2008]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tissue factor; Apoptosis; Migration; Chemotaxis; Simvastatin; Platelet Derived Growth Factor; Cell Signaling; Microparticles; Prostasomes; Trombosis; Coagulation; Prostate Cancer; Breast Cancer; Caspase-3; Caspase-8; NFkappaB; PAR2; Transactivation; Monocytes; MEDICINE Chemistry Clinical chemistry; MEDICIN Kemi Klinisk kemi;

    Sammanfattning : Background: Tissue factor (TF) is a 47 kDa transmembrane glycoprotein known as the main initiator of blood coagulation. TF is over-expressed on many malignant cells and apart from increasing the risk of thrombosis, the presence of TF/FVIIa also promotes the progression of cancer and metastasis by intracellular signaling. LÄS MER

  2. 2. Crosstalk Between Activated Platelets and the Complement System

    Detta är en avhandling från Uppsala : Universitetsbiblioteket

    Författare :Osama A. Hamad; Bo Nilsson; Kristina Ekdahl-Nilsson; Lennart Truedsson; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; platelets; activated platelets; TRAP; chondroitin sulfate; C1q; factor H; C4BP; C3; Compstatin; complement; platelet-leukocyte complexes; platelet microparticles; MEDICINE Microbiology; immunology; infectious diseases Immunology Clinical immunology; MEDICIN Mikrobiologi; immunologi; infektionssjukdomar Immunologi Klinisk immunologi; Klinisk immunologi; Clinical Immunology;

    Sammanfattning : Several studies have shown that complement and thrombotic events co-exist. Platelets have been suspected to act as the bridge between the two cascade systems. LÄS MER

  3. 3. Vitamin K-dependent protein S - studies of synthesis, structure and function

    Detta är en avhandling från Clinical Chemistry, Malmö

    Författare :Sofia Somajo; [2014]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; C4b-binding protein; coagulation; microparticles; protein C; protein S; structure; tissue factor pathway inhibitor;

    Sammanfattning : This thesis is based on four projects with the overall aim to investigate vitamin K-dependent protein S functions in relation to its structure. The anticoagulant functions of protein S can be divided in three: 1) cofactor for activated protein C (APC), 2) cofactor for tissue factor pathway inhibitor (TFPI) and 3) APC and TFPI-independent anticoagulant functions. LÄS MER

  4. 4. Clinical, epidemiological and molecular aspects of hemolytic uremic syndrome

    Detta är en avhandling från Lund University

    Författare :Lisa Sartz; [2010]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; O157; C3; microparticles; Shiga toxin; epidemiology; EHEC; hemolytic uremic syndrome; complement; tissue factor; atypical HUS;

    Sammanfattning : Hemolytic uremic syndrome (HUS) is the most common cause of acute renal failure in children in the western world. HUS is characterized by the triad of hemolytic anemia, thrombocytopenia and renal failure. There are two main subtypes of HUS; typical or D+ (D stands for diarrhea) HUS associated with enterohemorrhagic E. LÄS MER

  5. 5. Innate immune cell response in sepsis

    Detta är en avhandling från Department of Clinical Sciences, Lund University

    Författare :Yongzhi Wang; [2015]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Inflammation; abdominal sepsis; neutrophil; monocyte; platelet; coagulation; lung;

    Sammanfattning : Leukocyte recruitment is known to be a key feature at sites of inflammation and important in the combat against infectious agents. However, the mechanisms of leukocyte recruitment in the pulmonary microvasculature in response to local and systemic inflammation remain elusive. LÄS MER