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Visar resultat 16 - 20 av 23 avhandlingar som matchar ovanstående sökkriterier.

  1. 16. Genomic and epigenetic investigations of Silver-Russell syndrome and growth restriction

    Författare :Sara Bruce; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : A combination of genes, their epigenetic regulation, and the environment control the phenotypes of an individual, such as how short or tall one grows. Epigenetics refers to chemical modifications of DNA and histones that regulate gene activity and genome stability, and can take the form of, for example, addition of a methyl group to DNA. LÄS MER

  3. 17. Epstein-Barr virus and genomic instability : a new look at the mechanisms of viral oncogenesis

    Författare :Siamak Akbari Kamranvar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :EBV;

    Sammanfattning : EBV is associated with a variety of lymphoid and epithelial malignancies but the mechanisms of oncogenesis are still not fully understood. The aim of the work described in this thesis was to assess whether induction of genomic instability, as defined by the accumulation of non-clonal genetic aberrations, could play a role in EBV oncogenesis and identify the viral protein(s) responsible for this phenotype. LÄS MER

  4. 18. Structural variants in the great tit genome and their effect on seasonal timing

    Författare :Vinicius Henrique da Silva; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Sammanfattning : The biodiversity of our planet has been increasingly endangered by human actions. This nature biodiversity is strictly correlated with genomic diversity of all the species in the ecosystem. LÄS MER

  5. 19. Catching the Spore killers : Genomic conflict and genome evolution in Neurospora

    Författare :Jesper Svedberg; Hanna Johannesson; Mark A. Kirkpatrick; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Genomics; genomic conflict; genome evolution; meiotic drive; spore killer; suppression of recombination; inversions; fungi; Neurospora; Biologi; Biology;

    Sammanfattning : A genome is shaped by many different forces. Recombination can for instance both create and maintain genetic diversity, but the need to locally reduce recombination rates will also leave specific signatures. LÄS MER

  7. 20. Transcriptional regulation of neural development and degeneration

    Författare :Giulia Gaudenzi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The architecture and functional interactions of the cerebral cortex are fascinating in their complexity of billions of neurons and glial cells connected in intricate circuitries and spatial regions. During development, transcription factors and chromatin modifiers work together to coordinate gene expression programs that drive the formation of the cerebral cortex. LÄS MER