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Visar resultat 21 - 23 av 23 avhandlingar som matchar ovanstående sökkriterier.
21. Crosstalk between environmental signals and 3d genome organization in the regulation of gene expression
Sammanfattning : The thesis explores the connection between environmental stimuli and gene expression regulated by the spatial changes in genome organization. In Paper I, by applying state of the art Circular Chromosome Conformation Capture assay (4C) and Chromatin in situ Proximity (ChrISP) techniques, we show that transcriptionally active circadian genes meet in space with repressed lamina-associated domains (LADs), and that these interactions are under the control of the circadian clock. LÄS MER
22. Genetic studies of susceptibility to inflammation, autoimmunity, and hematological malignancy
Sammanfattning : The immune system represents the body’s defense against infectious organisms. Inborn defects of the immune system, called primary immunodeficiencies (PIDs), are a heterogeneous group of Mendelian disorders. Clinically, PIDs can cause isolated to broad susceptibility to pathogens, severe hyperinflammation, autoimmunity, allergy, and cancer. LÄS MER
23. Developing and democratizing tools for spatially resolved profiling of genome and transcriptome
Sammanfattning : The common thread of the work presented in this thesis is the development and democratization of tools that facilitate the spatial profiling of genome and transcriptome. Paper I describes iFISH, a resource that facilitates the large-scale design and costeffective, flexible production of probes for DNA FISH. LÄS MER
