Sökning: "Cholestatic Liver Disease"

Visar resultat 1 - 5 av 11 avhandlingar innehållade orden Cholestatic Liver Disease.

1. 1. Studies on mechanisms in liver fibrosis

   Författare :Nils Kinnman; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :bile duct epithelial cell; chernotaxis; cholestasis; cystic fibrosis; cystic fibrosis transmembrane conductance regulator; endothelin; hepatic stellate cell; hepatitis C virus; liver fibrosis; platelet-derived growth factor; platelet-derived growth factor receptor [beta]; smooth muscle [alpha]-actin; transforming growth factor- [beta]; tumor necrosis factor-[alpha];

   Sammanfattning : The aim of the present study was to elucidate mechanisms involved in liver fibrogenesis, the wound healing response of the liver to chronic injury. A role for TNF-[alpha] and all three isoforms of TGF-[beta] in the pathogenesis of hepatitis C related liver disease was suggested by the finding of increased expression of TGF-[beta]1-3, latent TGF-[beta] binding protein (LTBP), and TNF-[alpha] by immunohistochemistry in areas of inflammation and fibrosis in liver tissue from untreated patients with hepatitis C. LÄS MER

3. 2. Inflammatory bowel disease, colorectal neoplasia and treatment with ursodeoxycholic acid in primary sclerosing cholangitis

   Författare :Lina Lindström; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :inflammatory bowel disease;

   Sammanfattning : Background: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease closely associated with inflammatory bowel disease. PSC is progressive and ultimately leads to death or need for liver transplantation. Patients are also at high risk of developing colorectal neoplasia (CRN). LÄS MER

4. 3. Understanding the molecular mechanisms of bile acid receptor activation for the treatment of human liver disease

   Författare :Samer Al-Dury; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicinska sjukdomar; Gastroenterologi och hepatologi; FXR; IBAT; Gallsyror; Obesitas; Gallstenar;

   Sammanfattning : Farnesoid X receptor (FXR) is a nuclear transcription factor that is activated by bile acids and regulates bile acid homeostasis, glucose and lipid metabolism. FXR activation by a ligand has been identified as a therapeutic modality for a range of liver and metabolic diseases. LÄS MER

5. 4. Primary biliary cirrhosis : an epidemiological and clinical study based on patients from northern Sweden

   Författare :Per Uddenfeldt; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Primary biliary cirrhosis; incidence; prevalence; disease course; Kveim test; sarcoidosis; rheumatic disorders; lung function; diffusing capacity; Sjögren syndrome; von Willebrand factor;

   Sammanfattning : Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease, which primarily affects middle-aged women. The liver histology is characterized by inflammation and destruction of the intrahepatic bile ducts as well as a high frequency of granuloma. LÄS MER

7. 5. The role of fibroblast growth factor 19 in human liver

   Författare :Heléne Johansson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Bile acids are synthesized in the liver and are essential for intestinal absorption of lipids. Bile acid homeostasis is crucial and if not maintained, bile acids can accumulate to toxic levels and cause severe damage to the liver. LÄS MER