Sökning: "FXR"

Visar resultat 1 - 5 av 10 avhandlingar innehållade ordet FXR.

  1. 1. Understanding the molecular mechanisms of bile acid receptor activation for the treatment of human liver disease

    Författare :Samer Al-Dury; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicinska sjukdomar; Gastroenterologi och hepatologi; FXR; IBAT; Gallsyror; Obesitas; Gallstenar;

    Sammanfattning : Farnesoid X receptor (FXR) is a nuclear transcription factor that is activated by bile acids and regulates bile acid homeostasis, glucose and lipid metabolism. FXR activation by a ligand has been identified as a therapeutic modality for a range of liver and metabolic diseases. LÄS MER

  3. 2. Gut microbial regulation of bile acid metabolism and signaling

    Författare :Sama I. Sayin; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; Gut Microbiota; Bile Acids;

    Sammanfattning : The collection of microbes in our gastrointestinal tract, the gut microbiota, is an environmental factor that has profound impact on host health and disease. Bile acids are endogenous cholesterol-derived molecules that can be modified by the gut microbiota and function as signaling molecules in regulation of host metabolic processes. LÄS MER

  4. 3. Studies on cholesterol and bile acid metabolism in relation to plasma lipoproteins

    Författare :Beatrice Sjöberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The metabolism of cholesterol and bile acids is tightly controlled but only partially characterized. The liver is responsible for most of the clearance and catabolism of plasma cholesterol, and the hepatocyte expression of LDL receptors is central in this process. LÄS MER

  5. 4. Functional study of nuclear receptors and bile acids in the modulation of cholesterol homeostasis

    Författare :Xiaoli Hu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cholesterol carries multiple biological functions in the body, and imbalanced cholesterol metabolism leads to atherosclerosis and cardiovascular diseases. The present thesis aims to extend the knowledge of cholesterol metabolic regulation mediated by nuclear receptor LXRs and bile acids, two major players in the homeostasis of body cholesterol. LÄS MER

  7. 5. Bile acid metabolism in humans : regulation of synthesis and circadian rhythms

    Författare :Amani Al-Khaifi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Interfering with bile acids (BAs) signaling within the enterohepatic circulation (EHC) has recently emerged as an important way of controlling human metabolic homeostasis. This is highly relevant to a number of frequent disease entities such as dyslipidemia, fatty liver disease, insulin resistance, obesity, type 2 diabetes, gallstone disease and BA-induced diarrhea. LÄS MER