Sökning: "Cardiometabolic risk"

Visar resultat 21 - 25 av 70 avhandlingar innehållade orden Cardiometabolic risk.

1. 21. Translating Cardiac and Cardiometabolic GWAS Using Zebrafish

   Författare :Benedikt von der Heyde; Marcel den Hoed; Anastasia Emmanouilidou; Erik Ingelsson; Shawn Burgess; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GWAS; Zebrafish; Medicinsk genetik; Medical Genetics;

   Sammanfattning : Genome-wide association studies (GWAS) have identified thousands of loci associated with cardiac and cardiometabolic traits. However, the trait-associated variants usually do not clearly point to causal gene(s), mechanism(s) or tissue(s). Model systems that allow for a comprehensive and quick candidate gene screening are necessary, ideally in vivo. LÄS MER

3. 22. Cardiovascular risk factors, brain structure, and cognitive decline in old age : a population-based study

   Författare :Rui Wang; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Cardiovascular risk factors;

   Sammanfattning : This doctoral thesis investigated the burden of cardiovascular risk factors among older adults (age ≥60 years) living in central Stockholm (Study I) and the associations of these risk factors with structural brain characteristics and cognitive decline in aging, taking genetic background (APOE gene) into account (Studies II, III, and IV). All studies in this thesis use data from the Swedish National study on Aging and Care in Kungsholmen (SNAC-K) and the embedded SNAC-K Magnetic Resonance Imaging (MRI) study. LÄS MER

4. 23. Dietary carbohydrate quality and health : focus on low-grade systemic inflammation and cardiometabolic risk factors

   Författare :Nor Adila Mhd Omar; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Dietary carbohydrate quality, characterized by content of whole grain (WG), dietary fiber, and sugars, is important for human health. Whole grain consumption and cereal fiber can reduce the risk of chronic disorders such as cardiovascular disease (CVD) and type 2 diabetes, an effect partly mediated by alterations in cardiometabolic risk factors and low-grade systemic inflammation. LÄS MER

5. 24. Cathepsin S as a Biomarker of Low-grade Inflammation, Insulin Resistance, and Cardiometabolic Disease Risk

   Författare :Elisabeth Jobs; Johan Ärnlöv; Erik Ingelsson; Ulf Risérus; Göran Bergström; Uppsala universitet; []
   Nyckelord :epidemiology; cathepsin S; inflammation; insulin resistance; diabetes; mortality; cardiovascular mortality; cancer mortality; healthy Nordic diet.; Hälsa och välfärd;

   Sammanfattning : Cathepsin S is a protease important in major histocompatibility complex (MHC) class II antigen presentation and also in degrading the extracellular matrix. Studies, most of them experimental, have shown that cathepsin S is involved in different pathological conditions such as obesity, inflammation, atherosclerosis, diabetes, and cancer. LÄS MER

7. 25. Statistical advancements in analyzing accelerometer-measured physical activity intensity

   Författare :Jonatan Fridolfsson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; physical activity; accelerometry; cardiometabolic risk factors; cardiovascular disease; cardiorespiratory fitness; public health; statistics; multivariate; partial least squares; structural equation modelling;

   Sammanfattning : Physical activity (PA) is widely recognized as an important factor in preventing and treating cardiometabolic diseases and reducing mortality. Yet, the health implications of specific PA intensities and the intricate role of fitness in the relationship between PA and health remain less clear. LÄS MER