Sökning: "CYP1A2"

Visar resultat 11 - 15 av 29 avhandlingar innehållade ordet CYP1A2.

  1. 11. Metabolism of melatonin : with focus on the influence of cytochrome P4501A2

    Författare :Carina Ursing; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Melatonin; cytochrome P450 1A2 ; fluvoxamine; caffeine; tobacco smoke.;

    Sammanfattning : Melatonin (MT) regulates circadian rhythms. It is produced by pinealocytes. Their function is regulated by light. MT enters the blood stream by passive diffusion. LÄS MER

  3. 12. Clinical and experimental studies of organ-specific autoimmune diseases : With special reference to Addison's disease and autoimmune hepatitis : by Gennet Gebre-Medhin

    Författare :Gennet Gebre-Medhin; Uppsala universitet; []
    Nyckelord :Medical sciences; Addison s Disease; replacement therapy; DHEA; autoimmune hepatitis; APS I; autoantigen; cytochrome P4501A2; aromatic L-amino acid decarboxylase; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Sammanfattning : Organ-specific autoimmunity constitutes a large health problem, where both the clinical management and our understanding of the pathogenetic mechanisms need to improve. Women with Addison's disease have abnormally low levels of dehydroepiandrosterone (DHEA), its sulphate ester (DHEA-S) and androgens relative to age, and many patients complain of physical and mental fatigue and low stress tolerance. LÄS MER

  4. 13. Metabolic drug interactions in man : methodological aspects on in vivo studies

    Författare :Ylva Böttiger; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :drug interactions; drug metabolism; cytochrome P450; therapeutic drug monitoring; omeprazole; ketoconazole; tolterodine; ropivacaine; sirolimus; diltiazem; lamotrigine; humans;

    Sammanfattning : The aim of this thesis was to investigate methodological aspects on in vivo metabolic drug interaction studies in man. Five pharmacokinetic studies in healthy persons or patients are presented. Together, they represent a set of model studies to evaluate the occurrence of, and extent of metabolic drug interactions in vivo. LÄS MER

  5. 14. Variation and comparison of cytochromes P450 in human liver and blood : with special emphasis on gene expression

    Författare :Niklas Finnström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cytochrome P450; CY1A2; CYP1B1; CYP2E1; CYP3A4; gene expression; RTPCR; liver; blood; human; variation.;

    Sammanfattning : The liver is the major drug and xenobiotic metabolising organ, and is the target of many adverse reactions. The main hepatic metabolic enzymes belong to the mono oxygenase enzyme family of cytochromes P450 (CYP). Direct studies of these enzymes in small liver biopsy samples require ultrasensitive methodology. LÄS MER

  7. 15. Pharmacogenetics and Antipsychotic Treatment in Schizophrenia with Special Focus on Adverse Drug Reactions

    Författare :Arzu Gunes; Marja-Liisa Dahl; Maria Gabriella Scordo; Kristina I. Melkersson; Jürgen Brockmöller; Uppsala universitet; []
    Nyckelord :Medicine; Pharmacogenetics; schizophrenia; antipsychotic treatment; adverse effects; clinical outcome; Medicin;

    Sammanfattning : Genetically determined differences in drug metabolism and disposition and drug targets play a pivotal role in the interindividual variability in the clinical outcome of antipsychotic treatment. The aim of this thesis was to study the impact of polymorphisms in genes involved in the pharmacokinetics and pharmacodynamics of antipsychotics, with special focus on their extrapyramidal and metabolic adverse effects. LÄS MER