Sökning: "CYP1A2"

Visar resultat 6 - 10 av 29 avhandlingar innehållade ordet CYP1A2.

  1. 6. Epigenic regulation and posttranslational modification of human cytochrome P450s : focus on CYP2W1, CYP1A2 and CYP2C18

    Författare :Alvin V Gomez; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The cytochrome P450 superfamily represents a very important group of enzymes that are responsible for the metabolism of drugs as well as of endogenous compounds. Many P450s are genetically polymorphic causing important interindividual variability in P450 expression and activity whereas in some cases the basis for interindividual variation has still not been resolved. LÄS MER

  3. 7. Experimental design of phenotyping probe drugs with emphasis on CYP1A2 : their use in studies on genetic and environmental regulation of drug metabolism

    Författare :Magnus Christensen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Drug metabolism; phenotype; CYP1A2; caffeine; melatonin; fluvoxamine; omeprazole; losartan; debrisoquine; quinine; genotype; single nucleotide polymorphism;

    Sammanfattning : Assessment of the cytochrome (CYP) P450 enzyme activity or phenotyping is a method to characterise the real activity of an enzyme by the use of a marker probe drug. The information of the phenotype is of clinical relevance because it reflects the combined effects of genetic, environmental e.g. LÄS MER

  4. 8. Importance of pharmacogenetic and environmental factors for variation in caffeine disposition : with special emphasis on CYP1A2, CYP2A6, NAT2 and XO

    Författare :Natasa Djordjevic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Inter-individual variation in response to drugs conveys considerable risk of either therapy failure or drug toxicity. Caffeine, as one of the most frequently used psychoactive substances in the world, is not an exception, and both lack of effects and adverse reactions have been observed after usual doses. LÄS MER

  5. 9. Functional features of human cytochrome P450 1A2 : with special focus on caffeine and melatonin metabolism

    Författare :Anna Nordmark; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Drug metabolism; CYP1A2; caffeine; melatonin; liver slices; in vitro methods;

    Sammanfattning : CYP1A2 is one of the major cytochrome P450 enzymes in the liver and metabolises drugs such as caffeine, clozapine, tacrine, and theophylline. CYP1A2 also has a role in chemical carcinogenesis due to its activation of procarcinogens, such as heterocyclic amines and arylamines. Caffeine is extensively used to assess CYP1A2 activity. LÄS MER

  7. 10. Pharmacogenetics of drug metabolizing enzymes with special emphasis on Ethiopians

    Författare :Eleni Aklillu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Drug metabolism; gene duplication; CYP2D6; CYP2C19; CYP2C9; CYP1B1; CYP1A2; genotyping; xanthine oxidase; ultrarapid metabolizers; polymorphism; caffeine; Ets; dietary selection.;

    Sammanfattning : Pharmacogenetics of drug metabolising enzymes has been well studied in Caucasians and Asians, but relatively little in Africans. The aim of this thesis was to investigate the molecular genetics of drug metabolising enzymes, in particular CYP2D6, CYP2C19, CYP2C9, CYP1B1, CYP1A2 and XO, with special emphasis on the Ethiopian population. LÄS MER