Sökning: "alternative splice"
Visar resultat 1 - 5 av 75 avhandlingar innehållade orden alternative splice.
1. Regulation of alternative Pre-mRNA splicing : positive and negative control of adenovirus 3' splice site selection
Sammanfattning : .... LÄS MER
2. Understanding the Noise : Spliceosomal snRNA Profiling
Sammanfattning : The concept of the gene has been constantly challenged by new discoveries in the life sciences. Recent challenging observations include the high frequency of alternative splicing events and the common transcription of non-protein-coding-RNAs (ncRNAs) from the genome. The latter has long been considered noise in biological systems. LÄS MER
3. The balance of splicing : A novel insight into the splicing regulation of high-risk HPV E6 and E7 oncogenes
Sammanfattning : HPV is associated with several cancers. The genome consists of a long control region, early (E1, E2, E4, E5, E6 and E7) and late (L1 and L2) genes. The E6 and E7 proteins prevent cells from entering apoptosis and regulate the cell cycle. A deregulated expression of these can result in malignant transformations. LÄS MER
4. Alternative splicing of interleukin-7
Sammanfattning : Alternative splicing of pre-mRNA is the primary source of creating proteome diversity in humans; it is therefore highly relevant to disease and therapy. Alternative splicing has been described for many cytokines and these splice variants appear to function as either agonists or as antagonists of the wildtype cytokine. LÄS MER
5. CYP26B1 as regulator of retinoic acid in vascular cells and atherosclerotic lesions
Sammanfattning : Cardiovascular disease (CVD), currently the most common cause of morbidity and mortality worldwide, is caused mainly by atherosclerosis. Atherosclerosis is a chronic multifocal, immunoinflammatory, fibroproliferative disease of medium and large arteries. LÄS MER