Sökning: "Burkitt s lymphoma"

Visar resultat 1 - 5 av 13 avhandlingar innehållade orden Burkitt s lymphoma.

  1. 1. Role of latent EBV genes in the induction of genomic instability in Burkitt’s lymphoma

    Författare :Bettina Gruhne; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Epidemiological and molecular evidence link Epstein-Barr virus (EBV) infection to a variety of lymphoid and epithelial malignancies but the contribution of the virus to tumorigenesis is unclear. Genomic instability, defined by the establishment of a mutator phenotype and characterized by the occurrence of non-clonal chromosomal aberrations, excessive DNA damage and defects in DNA repair, is the hallmark of malignant transformation. LÄS MER

  3. 2. Impact of malaria on B-cell homeostasis and Epstein-Barr virus reactivation : endemic Burkitt's lymphoma pathogenesis

    Författare :Arnaud Chêne; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Over recent years, the concept that many diseases can be aetiologically linked to infection by more than one pathogen has gained increased attention and awareness. Plasmodium falciparum (P. LÄS MER

  4. 3. In silico analysis of pathways targeted by EBV infection and malignant transformation

    Författare :Ramakrishna Rao Sompallae; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Bioinformatics; systems biology; gene expression analysis; Epstein-Barr virus; Burkitt s lymphoma;

    Sammanfattning : Epstein-Barr virus (EBV) is a ubiquitous γ-herpes virus with dual cell tropism for human B-lymphocytes and epithelial cells. EBV infection is linked to several malignancies such as Burkitt s lymphoma (BL) and nasopharyngeal carcinoma (NPC). LÄS MER

  5. 4. Functional characterization of the alternative reading frame protein p14ARF

    Författare :Mikael Lindström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :p14ARF; p19ARF; alternative reading frame; CDKN2A; p53; B23; nucleophosmin; Burkitt´s lymphoma; nucleolus; senescence; Myc; E2F; phosphorylation; RNA interference; ribosome biogenesis;

    Sammanfattning : A deeper understanding of the molecular events underlying tumor development is a prerequisite for the design of novel and efficient therapies. Inactivation of the p53 and retinoblastoma (Rb) tumor suppressor pathways appears as a common theme in most malignant human tumors. LÄS MER

  7. 5. The role of the microenvironment on the regulation of Epstein-Barr virus latent gene expression

    Författare :Loránd Levente Kis; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Epstein-Barr virus (EBV) is a human-specific gamma-herpes virus of the Lymphocryptovirus genus that has succeeded to colonize more than 90% of the adult population. EBV s coevolution with humans has established a largely harmless co-existence that depends on the variability of viral gene expression and on the immunological host response. LÄS MER