Sökning: "Biochemistry : methods"

Visar resultat 11 - 15 av 350 avhandlingar innehållade orden Biochemistry : methods.

  1. 11. A structural genomics pilot project : methods and applications

    Författare :Ulrika Ericsson; Pär Nordlund; Elisabeth Sauer-Eriksson; Stockholms universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Structural biochemistry; Strukturbiokemi;

    Sammanfattning : With the availability of many completely sequenced genomes, scientific research has shifted from genes to the products of the genes, the proteins. Structural genomics groups have been established worldwide, with the objective of determining protein structures on a genome-wide scale. LÄS MER

  2. 12. Accelerating the discovery of drugs for Neglected Tropical Diseases using biophysical methods

    Författare :Giulia Opassi; Helena Danielson; Jenny Sandmark; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Neglected Tropical Diseases; Drug Discovery; Biochemistry; Biophysics; Kinetic; Fragment Based Lead Discovery; Assay Development;

    Sammanfattning : Even though they account for 10% of the global disease burden and besides the new record of funding in 2018, tropical diseases are still neglected by the majority of pharmaceutical companies and public funding. The reason can be mostly found in the fact that for these diseases a conventional drug discovery process is often too expensive. LÄS MER

  3. 13. Padlock Probe-Based Nucleic Acid Amplification Tests : Point-of-care Diagnostics of Infectious Diseases

    Författare :Sibel Ciftci; Mats Nilsson; Jonas Klingström; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Nucleic Acid Amplification; Isothermal Amplification Methods; Padlock Probes; Rolling Circle Amplification; Molecular Diagnostics; Infectious Disease Diagnostics; Virus; Point-of-Care; Biochemistry; biokemi;

    Sammanfattning : Recent advancements in molecular biology and biotechnology have pushed the field of molecular diagnostics much further to benefit the society towards smart access for rapid and simplified health care. In this context, point-of-care (PoC) technologies that bring the inventions in diagnostics closer to bedside settings draw attention. LÄS MER

  4. 14. Development of competence in biochemical experimental work : Assessment of complex learning at university level

    Författare :Christina Bergendahl; Lena Tibell; Lisbeth Lundahl; Lars-Owe Dahlgren; Umeå universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Teaching; experimental work; laboratory based project work; open experiments; biochemistry; life science; university level; action research; course design; aims and objectives; assessment; formative assessment; competence; complex learning; Didaktik; Subject didactics; Ämnesdidaktik; biokemi; Biochemistry;

    Sammanfattning : Biochemistry is part of life science: a fast developing multidisciplinary area. The overall aims of this thesis and the work underlying it were to find ways in which to develop competence in biochemistry at university level and to assess complex learning. A particular interest was the development of experimental work as a means to promote learning. LÄS MER

  5. 15. Free energy calculations of G protein-coupled receptor modulation : New methods and applications

    Författare :Willem Jespers; Hugo Gutiérrez-de-Terán; Johan Åqvist; Jonathan Essex; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; G protein-coupled receptor; adenosine receptor; molecular dynamics; free energy perturbation; homology modeling; computer simulations; conformational selectivity; binding free energy.; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Sammanfattning : G protein-coupled receptors (GPCRs) are membrane proteins that transduce the signals of extracellular ligands, such as hormones, neurotransmitters and metabolites, through an intracellular response via G proteins. They are abundant in human physiology and approximately 34% of the marketed drugs target a GPCR. LÄS MER