Sökning: "Pili"

Visar resultat 1 - 5 av 40 avhandlingar innehållade ordet Pili.

  1. 1. Construction of force measuring optical tweezers instrumentation and investigations of biophysical properties of bacterial adhesion organelles

    Detta är en avhandling från Umeå : Fysik

    Författare :Magnus Andersson; Umeå universitet.; [2007]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; optical tweezers; biological physics; unfolding; Escherichia coli; force measurements; energy landscape; dynamic force spectroscopy; manipulation; polymers; pili; NATURAL SCIENCES Physics; NATURVETENSKAP Fysik;

    Sammanfattning : Optical tweezers are a technique in which microscopic-sized particles, including living cells and bacteria, can be non-intrusively trapped with high accuracy solely using focused light. The technique has therefore become a powerful tool in the field of biophysics. LÄS MER

  2. 2. The mechanics of adhesion polymers and their role in bacterial attachment

    Detta är en avhandling från Umeå : Umeå universitet

    Författare :Johan Zakrisson; Umeå universitet.; [2015]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Pili; optical tweezers; bacterial adhesion; fimbriae; uncoiling;

    Sammanfattning : Bacterial resistance to antibiotics is increasing at a high rate in both developing and developed countries. To circumvent the problem of drug-resistant bacterial pathogens, we need to develop new effective methods, substances, and materials that can disarm and prevent them from causing infections. LÄS MER

  3. 3. Synthesis and biological evaluation of Bicyclic β-Lactams and 2-Pyridinones Pilicides Targeting Pilus Biogenesis in Pathogenic Bacteria

    Detta är en avhandling från Umeå : Department of Chemistry, Organic Chemistry, Umeå University

    Författare :Hans Emtenäs; Umeå universitet.; [2003]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; β-lactam; 2-pyridinone; 2-pyridone; Meldrum’s acid; Δ2-thiazoline; solid-phase synthesis; microwave assisted synthesis; antibacterial; pili; pilicide; Organisk kemi; NATURAL SCIENCES Chemistry Organic chemistry; NATURVETENSKAP Kemi Organisk kemi; organisk kemi; Organic Chemistry;

    Sammanfattning : New methods have been developed for the synthesis of bicyclic β-lactams and 2-pyridinones by combining acyl Meldrum’s acids and Δ2-thiazolines. The 2-pyridinones were synthesised both in solution using conventional heating or microwave assisted heating as well as by solid supported chemistry. LÄS MER

  4. 4. Peptidomimetics based on ring-fused 2-pyridones probing pilicide function in uropathogenic E. coli and identification of Aβ-peptide aggregation inhibitors

    Detta är en avhandling från Umeå : Kemi

    Författare :Veronica Åberg; Umeå universitet.; [2006]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; 2-pyridone; peptidomimetic; antibacterial; pili; Escherichia coli; virulence; amyloid; Alzheimer’s.; NATURAL SCIENCES Chemistry Organic chemistry; NATURVETENSKAP Kemi Organisk kemi;

    Sammanfattning : This thesis describes the synthesis and biological evaluation of highly substituted, ring-fused 2-pyridones. The utility of the bicyclic 2-pyridones to gain fundamental insights into the disease processes of bacterial infections and Alzheimer’s disease has been investigated. LÄS MER

  5. 5. Synthesis of substituted Ring-Fused 2-Pyridones and applications in chemical biology

    Detta är en avhandling från Umeå : Umeå universitet

    Författare :Christoffer Bengtsson; Umeå universitet.; [2013]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Synthesis; 2-pyridone; 2-thiazoline; cross coupling; pili; curli; antibacterial; organisk kemi; Organic Chemistry;

    Sammanfattning : Antibiotics have been extensively used to treat bacterial infections since Alexander Fleming’s discovery of penicillin 1928. Disease causing microbes that have become resistant to antibiotic drug therapy are an increasing public health problem. LÄS MER