Sökning: "G protein-coupled receptor"

Visar resultat 1 - 5 av 151 avhandlingar innehållade orden G protein-coupled receptor.

  1. 1. G protein-coupled receptor regulation: The role of protein interactions and receptor trafficking

    Detta är en avhandling från Experimentel medicinsk vetenskap, Lunds Universitet

    Författare :Caroline Sandén; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; receptor trafficking; B1 receptor; receptor oligomerization; estrogen; GPER1; G protein-coupled estrogen receptor 1; EP24.15; BK; bradykinin; B1R; B2R; B2 receptor; GPCR; receptor maturation;

    Sammanfattning : The superfamily of G protein-coupled receptors (GPCR) is the largest gene family in the human genome. GPCR-mediated signaling operates in every human cell, and about 50% of existing clinically useful drugs act through GPCR. LÄS MER

  2. 2. Free energy calculations of G protein-coupled receptor modulation New methods and applications

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Willem Jespers; Hugo Gutiérrez-de-Terán; Johan Åqvist; Jonathan Essex; [2020]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; G protein-coupled receptor; adenosine receptor; molecular dynamics; free energy perturbation; homology modeling; computer simulations; conformational selectivity; binding free energy.; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Sammanfattning : G protein-coupled receptors (GPCRs) are membrane proteins that transduce the signals of extracellular ligands, such as hormones, neurotransmitters and metabolites, through an intracellular response via G proteins. They are abundant in human physiology and approximately 34% of the marketed drugs target a GPCR. LÄS MER

  3. 3. Classification, Evolution, Pharmacology and Structure of G protein-coupled Receptors

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Malin C Lagerström; Helgi B. Schiöth; Robert Fredriksson; Anthony J. Harmar; [2006]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; Classification; Structure; Pharmacology; Evolution; G protein-coupled receptor; Farmakologi; MEDICINE Physiology and pharmacology Pharmacological research; MEDICIN Fysiologi och farmakologi Farmakologisk forskning;

    Sammanfattning : G protein-coupled receptors (GPCR) are integral membrane proteins with seven α-helices that translate a remarkable diversity of signals into cellular responses. The superfamily of GPCRs is among the largest and most diverse protein families in vertebrates. LÄS MER

  4. 4. Evolution of the G protein-coupled receptor signaling system Genomic and phylogenetic analyses

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Arunkumar Krishnan; Helgi Schiöth; Torgeir Hvidsten; [2015]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; GPCRs; G proteins; Sensory system; Signal transduction; Olfaction; Chemosensation; Hemichordates; Sponges; Porifera; Bilaterians; Holozoans; Fungi; Opisthokonts; Bioinformatics; Bioinformatik;

    Sammanfattning : Signal transduction pathways mediated by G protein-coupled receptors (GPCRs) and their intracellular coupling partners, the heterotrimeric G proteins, are crucial for several physiological functions in eukaryotes, including humans. This thesis describes a broad genomic survey and extensive comparative phylogenetic analysis of GPCR and G protein families from a wide selection of eukaryotes. LÄS MER

  5. 5. Electrophysiology-based investigations of G protein-coupled receptor pharmacology

    Detta är en avhandling från Stockholm : Karolinska Institutet, Dept of Clinical Neuroscience

    Författare :Richard Ågren; Karolinska Institutet.; Karolinska Institutet.; [2020]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : G protein-coupled receptors (GPCRs) constitute targets for ~34% of approved drugs. The muscarinic acetylcholine M2 receptor (M2R) activates G protein-coupled receptor inward rectifying potassium (GIRK) channels in the central nervous system and heart. Membrane potential modulates agonist potency at several GPCRs. LÄS MER