Sökning: "G protein-coupled receptor"

Visar resultat 1 - 5 av 145 avhandlingar innehållade orden G protein-coupled receptor.

  1. 1. G protein-coupled receptor regulation: The role of protein interactions and receptor trafficking

    Detta är en avhandling från Experimentel medicinsk vetenskap, Lunds Universitet

    Författare :Caroline Sandén; Lund University.; Lunds universitet.; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; receptor trafficking; B1 receptor; receptor oligomerization; estrogen; GPER1; G protein-coupled estrogen receptor 1; EP24.15; BK; bradykinin; B1R; B2R; B2 receptor; GPCR; receptor maturation;

    Sammanfattning : The superfamily of G protein-coupled receptors (GPCR) is the largest gene family in the human genome. GPCR-mediated signaling operates in every human cell, and about 50% of existing clinically useful drugs act through GPCR. LÄS MER

  2. 2. Classification, Evolution, Pharmacology and Structure of G protein-coupled Receptors

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Malin C Lagerström; Uppsala universitet.; [2006]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; Classification; Structure; Pharmacology; Evolution; G protein-coupled receptor; Farmakologi; MEDICINE Physiology and pharmacology Pharmacological research; MEDICIN Fysiologi och farmakologi Farmakologisk forskning;

    Sammanfattning : G protein-coupled receptors (GPCR) are integral membrane proteins with seven α-helices that translate a remarkable diversity of signals into cellular responses. The superfamily of GPCRs is among the largest and most diverse protein families in vertebrates. LÄS MER

  3. 3. Evolution of the G protein-coupled receptor signaling system Genomic and phylogenetic analyses

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Arunkumar Krishnan; Uppsala universitet.; [2015]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; GPCRs; G proteins; Sensory system; Signal transduction; Olfaction; Chemosensation; Hemichordates; Sponges; Porifera; Bilaterians; Holozoans; Fungi; Opisthokonts; Bioinformatik; Bioinformatics;

    Sammanfattning : Signal transduction pathways mediated by G protein-coupled receptors (GPCRs) and their intracellular coupling partners, the heterotrimeric G proteins, are crucial for several physiological functions in eukaryotes, including humans. This thesis describes a broad genomic survey and extensive comparative phylogenetic analysis of GPCR and G protein families from a wide selection of eukaryotes. LÄS MER

  4. 4. The Gene Repertoire of G protein-coupled Receptors New Genes, Phylogeny, and Evolution

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Þóra Kristín Bjarnadóttir; Uppsala universitet.; [2006]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; Bioinformatics; Evolution; GPCR; Phylogeny; Farmakologi; MEDICINE Physiology and pharmacology Pharmacological research; MEDICIN Fysiologi och farmakologi Farmakologisk forskning;

    Sammanfattning : The superfamily of G protein-coupled receptors (GPCRs) is one of the largest protein families of mammalian genomes and can be divided into five main families; Glutamate, Rhodopsin, Adhesion, Frizzled, and Secretin. GPCRs participate in most major physiological functions, contributing to the fact that they are important targets in drug discovery. LÄS MER

  5. 5. Synthesis and Structure of Novel G-Protein Coupled Receptor Ligands

    Detta är en avhandling från Stockholm : Stockholm University

    Författare :Magnus Brisander; Stockholms universitet.; [1998]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Structural Chemistry; strukturkemi;

    Sammanfattning : A method based on h6-arenetricarbonylchromium chemistry has been developed for the synthesis of enantiopure 4-alkylated 3-(dipropylamino)chromans. The stereochemistry of these new serotonergic ligands was determined by a combination of X-ray crystallography, NMR spectroscopy and chemical correlation. LÄS MER