Sökning: "BGP-15"

Hittade 5 avhandlingar innehållade ordet BGP-15.

  1. 1. Muscle Wasting in a Rat ICU Model : Underlying Mechanisms and Specific Intervention Strategies

    Författare :Heba Salah; Lars Larsson; Sven Tågerud; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; BGP-15; critical illness myopathy; janus kinase; intensive care unit; mechanical loading; muscle wasting; signal Transducer and Activator of Transcription; ventilator-induced diaphragm dysfunction; Anestesiologi och intensivvård; Anaesthesiology and Intensive Care; Clinical Neurophysiology; Klinisk neurofysiologi;

    Sammanfattning : Critical care has undergone several developments in the recent years leading to improved survival. However, acquired muscle weakness in the intensive care unit (ICU) is an important complication that affects severely ill patients and can prolong their ICU stay. LÄS MER

  3. 2. Critical illness myopathy : understanding different effects on muscle fibre function

    Författare :Hannah Ogilvie; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Skeletal muscle is an essential component of the human body, being one of the most dynamic and plastic tissues. As such it can be altered by numerous confounding factors. LÄS MER

  4. 3. Critical illness myopathy : mechanisms and pharmacological interventions

    Författare :Hazem Akkad; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The human body typically contains over 600 skeletal muscles that make up about 40% of total body weight. These muscles work together to perform functions such as locomotion, breathing, mastication, heat regulation and speech. LÄS MER

  5. 4. SUMOylation is a post-translational modification regulating skeletal muscle pathophysiology

    Författare :Gabriel Antonio Heras Arribas; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The research of this thesis is focused to investigate the role of SUMOylation, a protein post-translational modification reaction, implemented to the skeletal muscle pathophysiology area. SUMOylation is regulated by an enzymatic cascade of coordinated events capable of the reversible attachment of the Small Ubiquitin-like Modifier (SUMO) on to the targeted proteins. LÄS MER

  7. 5. The role of SUMO pathway in pathophsiology of skeletal muscle

    Författare :Arvind Venkat Namuduri; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Skeletal muscles are highly evolved and essential organs comprising 40 % of the total human body weight. They are essential in maintaining posture, energy metabolism, secrete hormones and act as central reserves for amino acids. LÄS MER