Sökning: "muscle wasting"

Visar resultat 1 - 5 av 27 avhandlingar innehållade orden muscle wasting.

  1. 1. Intensive Care Unit Muscle Wasting : Skeletal Muscle Phenotype and Underlying Molecular Mechanisms

    Författare :Sudhakar Reddy Aare; Larsson Lars; Rooyackers Olav; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; acute quadriplegic myopathy; gene expression; myosin; heat shock proteins; mechanical ventilation; myostatin; sepsis; corticosteroids; diaphragm; Clinical Neurophysiology; Klinisk neurofysiologi;

    Sammanfattning : Acute quadriplegic myopathy (AQM), or critical illness myopathy, is a common debilitating acquired disorder in critically ill intensive care unit (ICU) patients characterized by generalized muscle wasting and weakness of limb and trunk muscles. A preferential loss of the thick filament protein myosin is considered pathognomonic of this disorder, but the myosin loss is observed relatively late during the disease progression. LÄS MER

  2. 2. Muscle Wasting in a Rat ICU Model : Underlying Mechanisms and Specific Intervention Strategies

    Författare :Heba Salah; Lars Larsson; Sven Tågerud; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; BGP-15; critical illness myopathy; janus kinase; intensive care unit; mechanical loading; muscle wasting; signal Transducer and Activator of Transcription; ventilator-induced diaphragm dysfunction; Anestesiologi och intensivvård; Anaesthesiology and Intensive Care; Clinical Neurophysiology; Klinisk neurofysiologi;

    Sammanfattning : Critical care has undergone several developments in the recent years leading to improved survival. However, acquired muscle weakness in the intensive care unit (ICU) is an important complication that affects severely ill patients and can prolong their ICU stay. LÄS MER

  3. 3. Myonuclear Organization and Regulation of Muscle Contraction in Single Muscle Fibres : Effects of Ageing, Gender, Species, Endocrine Factors and Muscle Size

    Författare :Rizwan Qaisar; Lars Larsson; Jo Bruusgaard; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; single muscle cells; muscle nuclei; specific force; species; hypertrophy; mammals; ageing; gender; Physiology; Fysiologi;

    Sammanfattning : The skeletal muscle fibre is a syncitium where each myonucleus regulates the gene products in a finite volume of cytoplasm i.e., the myonuclear domain (MND). LÄS MER

  4. 4. Intensive care Muscle Wasting and Weakness : Underlying Mechanisms, Muscle Specific Differences and a Specific Intervention Strategy

    Författare :Guillaume Renaud; Lars Larsson; Oliver Friedrich; Uppsala universitet; []
    Nyckelord :;

    Sammanfattning : The intensive care unit (ICU) condition, i.e., immobilisation, sedation and mechanical ventilation, often results in severe muscle wasting and weakness as well as a specific acquired myopathy, i.e. LÄS MER

  5. 5. Mechanisms Underlying Intensive Care Unit Muscle Wasting : Intervention Strategies in an Experimental Animal Model and in Intensive Care Unit Patients

    Författare :Monica Llano-Diez; Lars Larsson; Marco Sandri; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; acute quadriplegic myopathy; intensive care unit; myosin; regulation of contraction; muscle atrophy; mechanical loading; mobilization; Clinical Neurophysiology; Klinisk neurofysiologi;

    Sammanfattning : Critically ill patients admitted to the intensive care unit (ICU) commonly develop severe muscle wasting and weakness and consequently impaired muscle function. This not only delays respirator weaning and ICU discharge, but has deleterious effects on morbidity, mortality, financial costs, and quality of life of survivors. LÄS MER