Sökning: "Autoantibody"

Visar resultat 6 - 10 av 118 avhandlingar innehållade ordet Autoantibody.

  1. 6. Array-based Autoantibody Profiling and Epitope Mapping

    Författare :Arash Zandian; Peter Nilsson; Jochen M. Schwenk; Maja Neiman; Morten Nielsen; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; antibody; antigens; peptide; epitope mapping; autoimmunity; autoantibodies; microarrays; Bioteknologi; Biotechnology;

    Sammanfattning : Antibodies are a class of proteins that are made by the immune system to recognize harmful organisms and molecules. Their exceptional capability of specifically recognizing molecules has been investigated for over a century and information thereof has been utilized for a variety of applications including vaccine and generation of therapeutic antibodies. LÄS MER

  3. 7. Aspects of autoantibody epitopes in type 1 diabetes

    Författare :Hanna Skärstrand; Celiaki och diabetes; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Minor autoantigens Neuropeptide Y.; Affinity; ZnT8 autoantibodies; Autoimmune type 1 diabetes;

    Sammanfattning : Type 1 diabetes (T1D) is strongly associated with autoantibodies against insulin (IAA), glutamic acid decarboxylase 65 (GADA), insulinoma-associated protein 2 (IA-2A) and the most recently identified zinc T8 transporter (ZnT8A). Together or alone, they are important both to predict T1D and to classify diabetes at the time of clinical onset. LÄS MER

  4. 8. Autoantibody recognition of collagen type II in arthritis

    Författare :Ingrid Lindh; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Autoantibodies against collagen type II (CII), a protein localized in the joint cartilage, play a major role in collagen-induced arthritis (CIA), one of the most commonly used animal models for rheumatoid arthritis (RA). The studies included in this thesis were undertaken to elucidate structural and functional requirements for B and T cells to recognize native CII structures during experimental arthritis as well as in human RA. LÄS MER

  5. 9. Affinity Arrays for Profiling Proteins and Autoantibody Repertoires

    Författare :Burcu Ayoglu; Peter Nilsson; Paul J. Utz; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : .... LÄS MER

  7. 10. Molecular studies on the autoantibody-mediated bone destruction in rheumatoid arthritis

    Författare :Akilan Krishnamurthy; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Autoantibody-positive rheumatoid arthritis (RA), also called seropositive RA, is characterised by the presence of anti citrullinated proteins antibodies (ACPA) that can be detected in blood several years before disease onset. Joint inflammation, pain and bone destruction are major features of the disease. LÄS MER