Sökning: "Autoantibody"

Visar resultat 11 - 15 av 118 avhandlingar innehållade ordet Autoantibody.

  1. 11. Pathogenetic mechanisms in irritable bowel syndrome

    Författare :Hans Törnblom; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Irritable bowel syndrome; functional gastrointestinal disorder; immunohistochemistry; full-thickness biopsy; enteric nervous system; autoantibody; gastroenteritis; risk factor;

    Sammanfattning : Aims of the thesis: To study new pathogenetic mechanisms in IBS; to find out if IBS is a neuromuscular disease affecting the small bowel; to study humoral factors in gut dysmotility associated with visceral neuropathy; and to study the natural history of post-infectious gastro-intestinal (GI) symptoms and risk factors for their development. Material and methods: In studies I and II, full-thickness jejunum biopsies from patients with severe IBS were investigated with immunohistochemistry. LÄS MER

  3. 12. Aspects of ZnT8 autoimmunity in childhood type 1 diabetes

    Författare :Cecilia K Andersson; Pediatrisk endokrinologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 diabetes; Zinc transporter; ZnT8 autoantibodies; HLA; islet cell autoantibodies; GAD65 autoantibodies; IA-2 autoantibodies; insulin autoantibodies; glucose tolerance;

    Sammanfattning : Type 1 diabetes is one of the most common chronic diseases in childhood and adolescence with an increasing incidence worldwide. It is an autoimmune disease with many autoimmune markers, where the zinc transporter 8 autoantibody (ZnT8A) is the most recent autoantibody discovered. LÄS MER

  4. 13. Characterization of immune specificities in idiopathic inflammatory myopathies

    Författare :Angeles Shunashy Galindo-Feria; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Idiopathic inflammatory myopathies (IIM or myositis) are a group of rheumatic autoimmune diseases characterised by skeletal muscle inflammation and weakness, and are associated with high morbidity and mortality. The diagnosis integrates several subgroups of muscular disorders with autoimmune backgrounds, where identifying myositis-specific and associated autoantibodies play an essential role. LÄS MER

  5. 14. Autoantibodies and the type I interferon system in idiopathic inflammatory myopathies

    Författare :Louise Ekholm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Idiopathic inflammatory myopathies (IIM), also known as myositis, are rare autoimmune diseases, characterized by proximal muscle weakness and inflammatory cells in skeletal muscle tissue. The most common subgroups are polymyositis (PM), dermatomyositis (DM) and inclusion body myositis (IBM). LÄS MER

  7. 15. Mixed connective tissue disease, myositis and systemic lupus erythematosus : immunological and genetic studies in three related rheumatic autoimmune studies

    Författare :Adla Bakri Hassan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MCTD; SLE; PM DM; autoantibodies; cytokines; MHC; polymorphisms.;

    Sammanfattning : Mixed connective tissue disease (MCTD), polymyositis (PM)/ dermatomyositis (DM) and systemic lupus erythematosus (SLE) are chronic, rheumatic, systemic inflammatory disorders. The disorders depend on several factors of both genetic and environmental origin. LÄS MER