Sökning: "Autoantibody"

Visar resultat 16 - 20 av 118 avhandlingar innehållade ordet Autoantibody.

  1. 16. On the analysis of antibody repertoires

    Författare :August Jernbom Falk; Peter Nilsson; Anna Månberg; Albert J.R. Heck; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; antibody repertoire; autoantibodies; serology; microarray; bead array; affinity proteomics; psychosis; SARS-CoV-2; COVID-19; post-COVID-19 condition; immunoglobulin; IgG; Biotechnology; Bioteknologi;

    Sammanfattning : The antibody repertoire is the ensemble of antibodies found in an individual at a given time. It displays high heterogeneity between individuals while being both largely temporally stable within an individual and rapidly responsive to immunological challenge. LÄS MER

  3. 17. Genetic regulation of autoantibodies in arthritis : lessons from mouse models

    Författare :Bruno Raposo; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Autoimmune diseases such as rheumatoid arthritis (RA) or multiple sclerosis (MS) are commonly regarded as complex or multifactorial diseases. This complexity regards to effector mechanisms involved in pathologic manifestations, and also to the diversity of genetic and environmental factors that predispose individuals to such diseases. LÄS MER

  4. 18. Immune responses to the Ro and La autoantigens

    Författare :Pia Tengnér; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Sjögren s syndrome; systemic lupus erythematosus; Ro SS-A; La SS-B;

    Sammanfattning : Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE) are rheumatic diseases characterized by autoantibody production directed to the Ro/SS-A and La/SS-B autoantigens. The Ro/SS-A is a complex of one of four small RNAs denoted hY RNAs, and three proteins; Ro 60kD, Ro 52kD and La. LÄS MER

  5. 19. On the profiling of autoantibodies in psychiatric disorders

    Författare :David Just; Peter Nilsson; Anna Månberg; Jochen M. Schwenk; Angela Vincent; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; affinity proteomics; microarrays; suspension bead array; autoantibodies; autoimmunity; psychiatric disorders; schizophrenia;

    Sammanfattning : There is a great need to increase our understanding of diseases affecting the brain and their underlying pathogenic mechanisms. To address this need, the work presented in this thesis applied affinity based proteomic techniques to profile proteins, and to investigate protein profiles and the autoantibody repertoire in brain related disorders. LÄS MER

  7. 20. Clinical and epidemiological project in cancer-associated dermatomyositis : the role of anti-TIF1γ antibodies

    Författare :Lara Dani; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of rare chronic autoimmune inflammatory diseases causing a debilitating muscle weakness but encountering even other symptoms such as arthritis, skin rash, lung involvement or dysphagia. IIM are a diagnostic challenge because of the clinical variability and the need to early identify the subgroups of disease with worst prognosis. LÄS MER