Sökning: "Androgen deprivation therapy"

Visar resultat 6 - 10 av 24 avhandlingar innehållade orden Androgen deprivation therapy.

  1. 6. The role of androgen in prostate cancer cell invasion

    Författare :Yin-Choy Chuan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Prostate cancer (PCa) is the most commonly diagnosed cancer in men in developed countries. Androgen deprivation therapy (ADT) is the mainstay treatment for patient diagnosed with PCa. However, the cancer will eventually relapse with metastatic cancer and become resistant to the treatment. LÄS MER

  3. 7. Invasive and Metastatic Properties of Advanced Prostate Cancer

    Författare :Karin Jennbacken; Göteborgs universitet; []
    Nyckelord :Prostate cancer; Androgen-independent; Castration-resistant; Metastasis; Invasion; Lymphangiogenesis; Cell adhesion; N-cadherin; VEGF-C; MRI;

    Sammanfattning : Prostate cancer is initially androgen-dependent (AD) and therefore androgen deprivation therapy (ADT) is generally used to treat advanced prostate cancer. However, the long-term treatment effects are insufficient and over time an androgen-independent (AI) tumor relapses, which is generally highly aggressive and metastatic. LÄS MER

  4. 8. Targeted therapeutic strategies for prostate cancer treatment using novel lipid kinase inhibitors in combination with current drugs

    Författare :Julius Semenas; Jenny L. Persson; Anna Berghard; Maria Fällman; Thomas Grundström; Lukas Kenner; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; bone metastasis; castration-resistant; treatment; precision therapy; PIP5K1A; steroid hormone receptors; cancer stem cells; Oncology; onkologi;

    Sammanfattning : Prostate cancer (PCa) is one of the most common cancer types and the fifth cancer-related cause of death among Western world men.  The sex steroid hormone, androgen and androgen receptor (AR) play important roles in PCa progression. LÄS MER

  5. 9. Molecular heterogeneity of prostate cancer bone metastasis

    Författare :Erik Bovinder Ylitalo; Pernilla Wikström; Anders Bergh; Maria Brattsand; Vessela Kristensen; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; CRPC; castration-resistant; androgen receptor; splice variant; abiraterone; cabazitaxel; ABCB1; cholesterol; Mdr1; P-gp; bone metastasis; immune response; metabolism; osteoblast; osteoclast; BMP; methylation;

    Sammanfattning : Castration-resistant prostate cancer (CRPC) develops after androgen deprivation therapy of advanced PC, often with metastatic growth in bone. Patients with metastatic CRPC have very poor prognosis. Growth of CRPC, in most but not all patients, seems to involve androgen receptor (AR) activity, despite castrate levels of serum testosterone. LÄS MER

  7. 10. Evaluation of regulator of G-protein signaling 2 (RGS2) at different stages of prostate cancer - Significance and clinical potential

    Författare :Anna Linder; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; Regulator of G-protein signaling 2 RGS2 ; castration-resistance; Androgen receptor; Prostate cancer bone metastases;

    Sammanfattning : Prostate cancer (PC) is often a slow-growing and symptom-free disease with good prognosis. However, a substantial number will progress, ultimately metastasize if left untreated and finally kill the patient. The standard treatment for these stages of PC is androgen deprivation therapy (ADT), which generally has an initially good clinical response. LÄS MER