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Visar resultat 1 - 5 av 715 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Metabolic Studies with Liquid Separation Coupled to Mass Spectrometry

   Författare :Erik Allard; Jonas Berguist; Per Sjöberg; Risto Kostiainen; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; liquid chromatography; mass spectrometry; tandem mass spectrometry; method development; capillary electrophoresis; electrospray ionization; time-of-flight; quantitation; metabolomics; metabonomics; pattern recognition; ximelagatran; melagatran; charge state; Analytical chemistry; Analytisk kemi; Analytical Chemistry; analytisk kemi;

   Sammanfattning : Metabolism is the sum of all chemical processes with the purpose to maintain life, as well as enable reproduction, in a living organism. Through the study of metabolism, increased understanding of pharmacological mechanisms and diseases can be achieved. LÄS MER

3. 2. Cerebrum Illuminans : Mass Spectrometric Analysis of Protein and Peptide Dynamics in Neurological Diseases

   Författare :Jörg Hanrieder; Jonas Bergquist; Malin Andersson; Ulf Hellman; Alma Burlingame; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mass spectrometry; central nervous system; neurological disease; proteomics; MALDI imaging; Analytical chemistry; Analytisk kemi; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

   Sammanfattning : The human brain (lat. cerebrum) is the most complex and heterogeneous organ in the human body. It is involved in a great number of body functions like movement, touch sensing, vision, hearing, smelling, hormone regulation and many more. In no other organ, the molecular communication mechanisms between different cells are so poorly understood. LÄS MER

4. 3. New Tools for Trapping and Separation in Gas Chromatography and Dielectrophoresis : Improved Performance by Aid of Computer Simulation

   Författare :Fredrik Aldaeus; Anders Colmsjö; Marja-Liisa Riekkola; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; gas chromatography; dielectrophoresis; computer simulation; finite element method; trapping; separation; lab-on-a-chip; Analytical chemistry; Analytisk kemi; Analytical Chemistry; analytisk kemi;

   Sammanfattning : Computer simulations can be useful aids for both developing new analytical methods and enhancing the performance of existing techniques. This thesis is based on studies in which computer simulations were key elements in the development of several new tools for use in gas chromatography and dielectrophoresis. LÄS MER

5. 4. Novel Solid Phase Extraction and Mass Spectrometry Approaches to Multicomponent Analyses in Complex Matrices

   Författare :Nahid Amini; Gunnar Thorsén; Tuulia Hyötyläinen; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Sample preparation; SPE; RAM; GCB µ-trap; GCB disk; High temperature LC; LC MS; ESI; APCI; Matrix effects; LIT-MS; SALDI; Sample screening; Oxidized GCB; Silicon nitride; Analytical chemistry; Analytisk kemi; Analytical Chemistry; analytisk kemi;

   Sammanfattning : Analysis of compounds present in complex matrices is always a challenge, which can be partly overcome by applying various sample preparation techniques prior to detection. Ideally, the extraction techniques should be as selective as possible, to minimize the concentration of interfering substances. LÄS MER

7. 5. Organophosphates and phthalates in air and dust from indoor environments : Method development and applied measurements

   Författare :Caroline Bergh; Conny Östman; Peter Haglund; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organophosphate esters; phthalate esters; air; dust; sampling; method development; GC MS; Analytical chemistry; Analytisk kemi; Analytical Chemistry; analytisk kemi;

   Sammanfattning : Organophosphate and phthalate esters are polymer additives that are frequently found in air and dust in indoor environments. This thesis describes the development and application of air sampling and selective mass spectrometric (MS) determination of these two compound groups. LÄS MER