Sökning: "Alzheimer s disease detection"
Visar resultat 6 - 10 av 10 avhandlingar innehållade orden Alzheimer s disease detection.
6. Fluorescent thiophene-based ligands for detection and characterization of disease-associated protein aggregates
Sammanfattning : In this thesis the unique optical properties of fluorescent ligands termed luminescent conjugated oligothiophenes (LCOs) have been used to study a variety of protein aggregates associated with human protein misfolding disease. This heterogeneous group of diseases contains well known and fatal members such as Alzheimer´s and Huntington´s disease and the development of sensitive tools for the detection and characterization of protein aggregates is crucial for unravelling the complexity of these pathologies. LÄS MER
7. Amyloid imaging in Alzheimer’s disease and mild cognitive impairment by positron emission tomography
Sammanfattning : Effectiveness of future treatment strategies in Alzheimer s disease (AD) will rely on early detection of disease and the possibility to clearly evaluate their effects. The findings presented in this thesis concerns both early in vivo detection of amyloid deposition in the brains of patients at risk of developing AD and the longitudinal changes of pathological and functional parameters in patients with AD. LÄS MER
8. Recombinant BRICHOS domains delivered over the blood-brain barrier : a possible way to treat Alzheimer’s disease
Sammanfattning : One of the current major challenges to treat neurological diseases is the ability of drug candidates to cross the blood-brain barrier (BBB). Alzheimer´s disease (AD) is the most common form of dementia worldwide, affecting more people every year due to a world where the average lifespan is increasing. LÄS MER
9. Detection, transfer and role of an environmentally spread neurotoxin (BMAA) with focus on cyanobacteria and the Baltic Sea region
Sammanfattning : β-N-methylamino-L-alanine (BMAA) is one of the more recently discovered bioactive compounds produced by cyanobacteria. BMAA is a non-protein amino acid reported present in human brain tissues of patients deceased from a neurodegenerative disease, such as Alzheimer´s disease or amyotrophic lateral sclerosis (ALS). LÄS MER
10. Mass spectrometric investigation of protein nitration in inflammation and neurodegeneration
Sammanfattning : The nitration of tyrosine seems to be very common in human diseases and at least forty different diseases have been reported to be associated with an increased nitration of proteins. The nitration of proteins results in a modification of tyrosine, 3-nitrotyrosine (3-NT), which is stable. LÄS MER
