Sökning: "Alzheimer´s disease"

Visar resultat 26 - 30 av 72 avhandlingar innehållade orden Alzheimer´s disease.

  1. 26. Cardiac and vascular pathology in Lewy body disease and Alzheimer's disease: exploring neurocognitive disorder beyond the brain

    Författare :Keivan Javanshiri; Lund Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The first aim of this thesis was to evaluate the prevalence of cardiovascular disease (CaVD), hypertension (HT), and type 2 diabetes mellitus (T2DM) in the neurodegenerative disorders Alzheimer’s disease (AD) and Lewy body disease (LBD). These conditions are considered modifiable risk factors for vascular dementia (VaD), and recent research has proposed its association with AD. LÄS MER

  3. 27. From cholesterol to oxidative stress in Alzheimer's disease : a wide perspective on a multifactorial disease

    Författare :Susanne Akterin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Epidemiological studies have provided evidence that high cholesterol levels in midlife and lack of antioxidants could render people more susceptible to develop AD. The aim of this thesis project was to get a more profound view of how cholesterol and oxidative stress could modify the development of Alzheimer s disease (AD) on the molecular level, by studying mechanisms of signal transduction. LÄS MER

  4. 28. The effect of physical activity and other lifestyle factors on dementia, Alzheimer’s disease and structural brain changes

    Författare :Suvi Rovio; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Dementia; Alzheimer´s disease; physical activity; lifestyle factors; apoE; brain volume; white matter lesions;

    Sammanfattning : Dementia is one of the major public health concerns and its impact is increasing rapidly in aging populations. Recent research has suggested that the origin of dementia and Alzheimer´s disease (AD), which is the most common form of dementia, is multifactorial including both genetic and environmental factors. LÄS MER

  5. 29. Interactive mechanism between beta-amyloid process, alfa7 nicotinic receptor, glial cell activation and oxidative stress in Alzheimer's disease

    Författare :Wen-Feng Yu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Abeta; Alzheimer s disease; astrocytes; brain development; nAChRs; neuritic plaques oxidative stress; transgenic mice; knockout mice;

    Sammanfattning : Alzheimer’s disease (AD) is the most common form of dementia with pathological features including the accumulation of neuritic plaques (NPs) and neurofibrillary tangles (NFTs). These degenerative processes are also accompanied by impaired cholinergic transmission, oxidative stress, activated glia and inflammation reaction. LÄS MER

  7. 30. Inflammation-associated risk factors for Alzheimer's disease and dementia

    Författare :Ulrika K Eriksson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alzheimer's disease (AD) is the leading cause of dementia worldwide and a highly debilitating, and deadly, disease. For the majority of AD cases, the cause of the disease is not known. Chronic inflammation has been implicated in AD pathology. LÄS MER