Sökning: "Alzheimer´s disease"

Visar resultat 11 - 15 av 72 avhandlingar innehållade orden Alzheimer´s disease.

  1. 11. Amyloid β-protein, Cystatin C and Cathepsin B as Biomarkers of Alzheimer's Disease

    Författare :Johan Sundelöf; Lars Lannfelt; Lena Kilander; Hans Basun; Johan Sundstrom; Laura Fratiglioni; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer´s disease; amyloid β-protein; cystatin C; cathepsin B; biomarkers; risk factors; epidemiology; Geriatrics and medical gerontology; Geriatrik och medicinsk gerontologi; Medicin; Medicine;

    Sammanfattning : It is suggested that Alzheimer’s disease (AD) is caused by an imbalance between production, degradation and clearance of the amyloid-β (Aβ) protein. This imbalance leads to aggregation of Aβ and tau proteins and neurodegeneration in the brain. LÄS MER

  3. 12. Mental stimulation and multimodal trials to prevent cognitive impairment and Alzheimer ́s disease

    Författare :Anders Rydström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Theoretical models of dynamic biomarkers underlying the development of Alzheimer´s Disease (AD) acknowledge that there is inter-individual variability in the cognitive performance associated with any level of AD pathology. Mentally stimulating activities such as schooling, occupation, and leisure activities, may contribute to this variability, but it is yet unclear how this can be best assessed, and how such effects can vary across AD severity and among individuals at-risk for cognitive impairment. LÄS MER

  4. 13. Alzheimer´s disease-related amyloid precursor protein and presenlin genes : normal function and pathophysiology

    Författare :Fiona Flood; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alzheimer's disease (AD) is characterised neuropathologically by the presence of plaques and tangles in the brain. AD can be sub-grouped into early onset (EOAD, age of onset ... LÄS MER

  5. 14. Proteomic strategies for analysis of cerebrospinal fluid in neurodegenerative disorders

    Författare :Sara Folkesson Hansson; Göteborgs universitet; []
    Nyckelord :Alzheimer?s disease; frontotemporal dementia; cerebrospinal fluid; neurodegeneration; proteomics; mass spectrometry; prefractionation; protein identification; quantification;

    Sammanfattning : ABSTRACT There is a great need for biomarkers to diagnose neurodegenerative disorders, such as the cognitive disorders Alzheimer?s disease (AD) and frontotemporal dementia (FTD). Cerebrospinal fluid (CSF) is in contact with the extracellular fluid of the brain and is consequently a valuable medium for identifying biomarkers for neurological disorders. LÄS MER

  7. 15. Amyloid β peptide: from monomer solubility to fibril structure

    Författare :Veronica Lattanzi; NanoLund: Centre for Nanoscience; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Alzheimer´s disease; Aβ solubility; small angle scattering; number of filaments; Aβ40; Aβ42 and Aβ42 S26Q ; fibril structure;

    Sammanfattning : Alzheimer´s disease (AD) is the most common human neuro-degenerative disease characterized by the formation of cerebral plaques. Several are the amyloid-beta (Aβ) variants found in the brain of healthy individuals. LÄS MER