Sökning: "Acute lymphoblastic leukemia ALL"

Visar resultat 41 - 45 av 73 avhandlingar innehållade orden Acute lymphoblastic leukemia ALL.

  1. 41. Studies of congenital genetic aberrations behind childhood leukemia

    Författare :Benedicte Bang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Acute lymphoblastic leukemia (ALL) is the most common cancer in childhood, and most frequently (85%) of B-cell precursor type (BCP-ALL). Acquired chromosomal rearrangements or aneuploidies are the recurrent, often prenatal, initiators of BCP-ALL. LÄS MER

  3. 42. Targeting polo-like kinase 1 in pediatric leukemia

    Författare :Oksana Goroshchuk; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Acute lymphoblastic leukemia (ALL) is one of the most common cancers among children in the world, with almost 90% complete remission rate after the primary treatment. However, some patients are resistant to treatment and some relapse later. Moreover, existing treatments are toxic and induce life-long adverse effects. LÄS MER

  4. 43. Preservation of male fertility in childhood acute leukemia : an experimental study addressing novel strategies and putative risks

    Författare :Mi Hou; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Although treatment of cancer in young boys with cytotoxic agents has long been known to cause infertility in the survivors, the mechanisms underlying drug-induced damage to the immature testis remain unclear. A number of clinical issues associated with transplantation of testicular germ cells or tissues also require clarification. LÄS MER

  5. 44. Transcriptional regulation and effects on differentiation by LMO proteins and the basic helix-loop-helix factors TAL1 and HEN1

    Författare :Anders Hansson; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetik; cytogenetik; cytogenetics; Genetics; HEN1; differentiation; LMO; LIM proteins; TAL1; T-ALL; bHLH;

    Sammanfattning : Acute lymphoblastic leukemia (ALL) is the most widespread type of cancer, as well as the most frequent leukemia in children. Malignant ALL cells originate from normal T lymphocytes or B cells that are blocked at immature stages of differentiation. LÄS MER

  7. 45. Molecular studies of prognostic and etiological factors in childhood leukemia

    Författare :Vasilios Zachariadis; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Acute lymphoblastic leukemia (ALL) is the most common cancer in childhood. It is caused by the somatic acquisition of genetic abnormalities and malignant transformation of immature lymphocytes in the bone marrow, most commonly of B-cell lineage. LÄS MER