Visar resultat 1 - 5 av 9 avhandlingar innehållade ordet β-lactamases.
Sammanfattning : Antibiotic resistance is increasing worldwide and is considered a severe threat to public health. Often, antibiotic resistance is caused by antibiotic resistance genes, of which many are hypothesized to have been transferred into human pathogens from environmental bacteria. LÄS MER
Sammanfattning : Enterobacteriaceae is a family of bacteria including Escherichia coli and Klebsiella pneumoniae that are common colonizers of the gastrointestinal tract. Extended spectrum β- lactamases (ESBL) are bacterial enzymes that degrade β-lactam antibiotics and thus make the bacteria resistant to β-lactam antibiotics. LÄS MER
Sammanfattning : The ß-lactam antibiotics are the most important antibacterial agents in the treatment of infectious diseases. A severe problem in ß-lactam therapy is the emergence of ß-lactam resistant bacteria. Clinical ß-lactam resistance is most often due to the production of ß-lactamases. ß-lactamase genes reside either on plasmids or on the chromosome. LÄS MER
Sammanfattning : Antibiotic resistance is an increasingly difficult problem in the clinic, where conventional antibiotics are failing, and new alternative solutions are in high demand. Infections caused by Gram-negative bacteria with multi drug resistance (MDR) mechanisms are increasing globally, and treatment options are limited. LÄS MER
Sammanfattning : The emergence of extended spectrum β-lactamase (ESBL) producing Enterobacteriaceae worldwide has led to an increased use of carbapenems and may drive the development of carbapenem resistance. Existing mechanisms are mainly due to acquired carbapenemases or the combination of ESBL-production and reduced outer membrane permeability. LÄS MER