Sökning: "β-lactamases"

Visar resultat 1 - 5 av 12 avhandlingar innehållade ordet β-lactamases.

  1. 1. New antibiotic resistance genes and their diversity

    Författare :Fanny Berglund; Chalmers tekniska högskola; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; metagenomics; β-lactamases; hidden Markov model; antibiotic resistance; carbapenemases; big data; tetracycline resistance;

    Sammanfattning : Antibiotic resistance is increasing worldwide and is considered a severe threat to public health. Often, antibiotic resistance is caused by antibiotic resistance genes, of which many are hypothesized to have been transferred into human pathogens from environmental bacteria. LÄS MER

  3. 2. Plasmid mediated antibiotic resistance : with focus on extended spectrum β-lactamases (ESBL)

    Författare :Alma Brolund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Enterobacteriaceae is a family of bacteria including Escherichia coli and Klebsiella pneumoniae that are common colonizers of the gastrointestinal tract. Extended spectrum β- lactamases (ESBL) are bacterial enzymes that degrade β-lactam antibiotics and thus make the bacteria resistant to β-lactam antibiotics. LÄS MER

  4. 3. Chromosomal β-lactamases in enterobacteria and in vivo evolution of β-lactam resistance

    Författare :Sven Bergström; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gram negative bacteria; ß-lactamase genes; divergence of neighbouring cperons; ß-lactamase hyperproduction; evolution of control sequences;

    Sammanfattning : The ß-lactam antibiotics are the most important antibacterial agents in the treatment of infectious diseases. A severe problem in ß-lactam therapy is the emergence of ß-lactam resistant bacteria. Clinical ß-lactam resistance is most often due to the production of ß-lactamases. ß-lactamase genes reside either on plasmids or on the chromosome. LÄS MER

  5. 4. Studies on two bacterial resistance mechanisms to β-lactam antibiotics : extended spectrum β-lactamases in Klebsiella oxytoca and methicillin resistance in staphylococci

    Författare :Shang Wei Wu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Eleven clinical isolates of Klebsiella oxytoca from Stockholm hospitals were found to be resistant to aztreonam and cefuroxime (MIC > 16 mg/L). The resistance was caused by a ß-lactamase with pI 5.25 and designated KH. Assay of the substrate profiles revealed that the KH ß-lactarnase was similar to the chromosomally encoded OXY-2 ß-lactamase. LÄS MER

  7. 5. Development of phosphorus-containing metallo-β-lactamase inhibitors : Synthesis and binding studies by solution NMR and molecular docking

    Författare :Katarzyna Palica; Máté Erdélyi; Christopher J. Schofield; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MBL inhibitors; antibiotic resistance; metallo-β-lactamases; NMR spectroscopy; Medicinal Chemistry; Läkemedelskemi;

    Sammanfattning : The rapidly growing bacterial resistance development is turning into one of the main challenges of the 21st century. Our antibiotics are becoming ineffective for the treatment of bacterial infections, and without successful action, simple infections, such as pneumonia or Septicemia, will soon carry a highly probable mortal prognosis. LÄS MER