Sökning: "β-lactamases"

Visar resultat 6 - 10 av 12 avhandlingar innehållade ordet β-lactamases.

  1. 6. Interactions between innate immune effectors and multidrug resistant bacteria

    Författare :Harpa Káradóttir; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Antibiotic resistance is an increasingly difficult problem in the clinic, where conventional antibiotics are failing, and new alternative solutions are in high demand. Infections caused by Gram-negative bacteria with multi drug resistance (MDR) mechanisms are increasing globally, and treatment options are limited. LÄS MER

  3. 7. Mechanisms and Dynamics of Carbapenem Resistance in Escherichia coli

    Författare :Marlen Adler; Linus Sandegren; Josep Casadesús; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; carbapenem; antibiotic resistance; fitness cost; ESBLs; penicillin-binding proteins; gene amplification;

    Sammanfattning : The emergence of extended spectrum β-lactamase (ESBL) producing Enterobacteriaceae worldwide has led to an increased use of carbapenems and may drive the development of carbapenem resistance. Existing mechanisms are mainly due to acquired carbapenemases or the combination of ESBL-production and reduced outer membrane permeability. LÄS MER

  4. 8. β-lactam combinations against multidrug-resistant Enterobacterales : Exploring combination effects and resistance development

    Författare :Lisa Allander; Thomas Tängdén; Linus Sandegren; Pernilla Lagerbäck; Arnfinn Sundsfjord; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gram-negative bacteria; antibiotic combination therapy; antibiotic resistance; beta-lactams; beta-lactamase inhibitors; Infektionssjukdomar; Infectious Diseases;

    Sammanfattning : The β-lactam antibiotics are a cornerstone in treating bacterial infections, but the increasing prevalence of antibiotic resistance worldwide threatens their effectiveness. The main driver of β-lactam resistance is the production of β-lactamases, which are bacterial enzymes that inactivate the antibiotic. LÄS MER

  5. 9. A world inside : Gastrointestinal microbiota in healthy Swedish children at day care centers and aspects on antibiotic resistance, enteric pathogens and transmission

    Författare :Johan Kaarme; Tryggve Nevéus; Björn Olsen; Jonas Ludvigsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ESBL; VRE; enteropathogens; antibiotic resistance; children; preschool; Pediatrik; Pediatrics;

    Sammanfattning : Antibiotic resistance is a growing threat to human health and is defined by the World Health Organization as a crisis that must be managed with the utmost urgency. Antibiotic resistant bacteria increase both mortality and morbidity and have a great impact on the global economy. LÄS MER

  7. 10. Identification of novel antibiotic resistance genes through large-scale data analysis

    Författare :Fanny Berglund; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; metagenomics; hidden Markov model; carbapenemases; antibiotic resistance; big data; carbapenemases;

    Sammanfattning : Antibiotic resistance is increasing worldwide, and is considered a serious threat to public health by e.g. the World Health Organization. Antibiotic resistance genes are hypothesized to originate from harmless bacteria in and around us, from where they are horizontally transfered into human pathogens. LÄS MER