Sökning: "microglia"

Visar resultat 6 - 10 av 170 avhandlingar innehållade ordet microglia.

  1. 6. The role of glial cells in alpha-synuclein pathology : Focus on degradation, cell-to-cell propagation and inflammation

    Författare :Jinar Rostami; Anna Erlandsson; Martin Ingelsson; Joakim Bergström; Michael Heneka; Uppsala universitet; []
    Nyckelord :Parkinson’s disease; alpha-synuclein; amyloid-beta; astrocytes; microglia; tunneling nanotubes; antigen presentation; T cells; glial crosstalk; degradation; KYP-2407; Medicinsk vetenskap; Medical Science;

    Sammanfattning : Growing evidence emphasizes the role of astrocytes and microglia in Parkinson’s disease (PD) and Alzheimer’s disease (AD). Yet, little is known about their impact on specific disease processes and if their involvement is beneficial or detrimental. LÄS MER

  3. 7. The role of myeloid cells in neurodegenerative diseases. Studies on cellular phenotype and communication

    Författare :Yiyi Yang; Neuroinflammation; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Microglia; Neuroinflammation; Alzherimer’s disease; Stroke; Innate immune system; Systemic inflammation; Monocytes; Single-cell sequencing;

    Sammanfattning : Neurological disorders are listed as the second leading cause of death worldwide. Stroke and Alzheimer’s disease (AD) are the major contributors to neurological disorders of deaths. Every year, around 14 million new people are affected by stoke and nearly 10 million new cases of AD are diagonosed worldwide. LÄS MER

  4. 8. Microglial Glutamate Transporters - Regulation of Expression and Possible Physiological Functions

    Författare :Mikael Persson; Göteborgs universitet; []
    Nyckelord :anaphylatoxin; central nervous system; herpes simplex virus; glutamate transport; glutathione; GLT-1; lipopolysaccharide; microglia; neuroinflammation; oxidative stress; protection; tumour necrosis factor-alpha;

    Sammanfattning : Microglia are considered as the immunocompetent cells of the central nervous system (CNS). Being the first line of defence, they have prominent roles in monitoring the homeostasis and the extracellular milieu and can rapidly and specifically react to any disturbances such as brain trauma, ischemia, neurodegenerative diseases, or infections. LÄS MER

  5. 9. Induction of the cytoskeletal protein radixin in the adult brain

    Författare :Åsa Persson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rostral migratory stream; stroke; Neural stem cells; microglia; ezrin radixin moesin; Olig2;

    Sammanfattning : Abstract Neural stem and progenitor cells (NSPCs) proliferate throughout life in two regions of the brain, namely the subventricular zone (SVZ) of the lateral ventricles and the subgranular zone of dentate gyrus in the hippocampus. In the adult SVZ, NSPCs give rise to neuroblasts that leave the SVZ for long distance migration along the rostral migratory stream (RMS), on their way to the olfactory bulb where they mature and are integrated in the neural network. LÄS MER

  7. 10. Neurogenic and inflammatory response in the rodent brain following stroke

    Författare :Ursula Heldmann; Lund Neurologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; inflammation; Mac-1-saporin; TNF-a; Neurogenesis; Microglia; stroke; aging;

    Sammanfattning : Stroke and in this case cerebral infarction affects 20 million people each year and five million of them die. In Sweden 30-35000 people will be affected and one of three of them will be severely disabled. In addition, one of six will suffer a new stroke within six years. LÄS MER