Sökning: "lipopolysaccharide"

Visar resultat 1 - 5 av 223 avhandlingar innehållade ordet lipopolysaccharide.

  1. 1. Vascular actions of antimicrobial peptides

    Författare :Cristina Ciornei; Sektion II; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kardiovaskulära systemet; Cardiovascular system; vascular smooth muscle; sepsis; nitric oxide; human antimicrobial peptide LL-37; Antimicrobial peptides; lipopolysaccharide; bactericidal permeability-increasing protein;

    Sammanfattning : The present thesis focuses on the vascular effects of antimicrobial peptides especially mechanisms involving the vasodilator nitric oxide (NO), which is released from the blood vessel wall during inflammatory conditions such as sepsis. Bacterial lipopolysaccharide stimulates the expression of nitric oxide synthase (iNOS), which increases the NO production in vascular tissues or cultured vascular smooth muscle cells (VSMC). LÄS MER

  3. 2. Studies of the pathogenesis of hemolytic uremic syndrome and thrombotic thrombocytopenic purpura

    Författare :Diana Karpman; Lund Pediatrik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pediatri; Pediatrics; tumor necrosis factor; interleukin 6; von Willebrand factor; apoptosis; lipopolysaccharide; shiga-like toxin; Escherichia coli O157:H7; Hemolytic uremic syndrome; thrombotic thrombocytopenic purpura; Urology; nephrology; Urologi; nefrologi;

    Sammanfattning : This study investigated the pathogenesis of hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP). (1) The relative roles of lipopolysaccharide and Shiga-like toxin-2 were studied in a mouse model of Escherichia coli O157:H7 infection. LÄS MER

  4. 3. Physiology of Escherichia coli in batch and fed-batch cultures with special emphasis on amino acid and glucose metabolism

    Författare :Ling Han; KTH; []
    Nyckelord :escherichia coli; amino acids; glycine; quorum sensing; metabolic switch; metabolite po9ols; carbon balance; outer membrne; lipopolysaccharide; batch culture;

    Sammanfattning : The objective of this work is to better understand themetabolism and physiology ofEscherichiacoli(W3110) in defined medium cultures with thelong-term goal of improving cell yield and recombinant proteinproductivity.The order of amino acid utilization inE. colibatch cultures was investigated in a medium with16 amino acids and glucose. LÄS MER

  5. 4. Modulating Organ Dysfunction in Experimental Septic Shock : Effects of Aminoglycosides, Antiendotoxin Measures and Endotoxin Tolerance

    Författare :Markus Castegren; Jan Sjölin; Claes Frostell; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lipopolysaccharide; animal model; pig; tobramycin; endotoxin elimination; immunoparalysis; secondary sepsis; Infectious diseases; Infektionssjukdomar; Infektionssjukdomar; Infectious Diseases;

    Sammanfattning : Sepsis is a common diagnose in the intensive care population, burdened with a high mortality. The systemic inflammatory reaction underlying the development of septic organ dysfunction can be modeled using Gram-negative bacterial lipopolysaccharide, endotoxin. LÄS MER

  7. 5. Pharmacometrics to characterize innate immune response and antibacterial treatments

    Författare :Anders Thorsted; Lena E. Friberg; Elisabet I. Nielsen; Mats O. Karlsson; Gauri G. Rao; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacometrics; non-linear mixed effects modelling; modelling; pharmacokinetics; pharmacodynamics; pkpd; antibiotics; cefuroxime; piperacillin; phagocytes; lipopolysaccharide; endotoxin; porcine endotoxemia; challenge studies; sepsis; critically ill; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : The immune system protects the host against pathogens by distinguishing self from non-self. However, it is most-often disregarded in pharmacokinetic-pharmacodynamic (PKPD) characterization of (new and old) antibiotics. LÄS MER