Sökning: "glial crosstalk"
Hittade 4 avhandlingar innehållade orden glial crosstalk.
1. The role of glial cells in alpha-synuclein pathology : Focus on degradation, cell-to-cell propagation and inflammation
Sammanfattning : Growing evidence emphasizes the role of astrocytes and microglia in Parkinson’s disease (PD) and Alzheimer’s disease (AD). Yet, little is known about their impact on specific disease processes and if their involvement is beneficial or detrimental. LÄS MER
2. Roles of Notch signalling in early embryonic development
Sammanfattning : Metazoan embryonic development requires a complex interplay of morphological processes coordinated with self-renewal and differentiation to correctly specify and maintain body cell types in the correct location. Notch signalling is a metazoan specific arbiter of cell fate decision processes, known to control lateral inhibition and asymmetric cell division processes throughout the metazoa and in the development of all metazoan organs. LÄS MER
3. A stargazer's guide to neurodegeneration : Astrocytes' role in the propagation of pathological proteins
Sammanfattning : Alzheimer’s disease (AD) and Parkinson’s disease (PD) are characterized by brain accumulation of pathogenic protein aggregates. In the AD brain, amyloid-β (Aβ) and tau form plaques respective tangles, while in the PD brain α-synuclein (α-syn) form Lewy bodies and Lewy neurites. LÄS MER
4. Lysosomal network proteins as biomarkers and therapeutic targets in neurodegenerative disease
Sammanfattning : The pre-symptomatic stage of neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) occurs several decades before the clinical onset. Changes in the lysosomal network, i.e. the autophagosomal, endosomal and lysosomal vesicular system, are among the first alterations observed. LÄS MER