Sökning: "alpha"

Visar resultat 1 - 5 av 1109 avhandlingar innehållade ordet alpha.

  1. 1. Alpha-Synuclein Oligomers Cellular Mechanisms and Aspects of Antibody Treatment

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Gabriel Gustafsson; Uppsala universitet.; [2017]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s Disease; Alpha-synuclein; Aggregation; Oligomers; Monoclonal Antibody; Glia; Astrocyte; Immunofluorescence; Medicinsk vetenskap; Medical Science;

    Sammanfattning : In Parkinson’s disease (PD) and dementia with Lewy bodies (DLB), aggregated α-synuclein deposit inside cells within the brain. Smaller soluble α-synuclein aggregates, oligomers, are present both intra- and extracellularly. LÄS MER

  2. 2. On Alpha-decay and Alpha Clustering

    Detta är en avhandling från Zagreb University

    Författare :Gordana Dodig-Crnkovic; Göteborgs universitet.; University of Gothenburg.; Chalmers tekniska högskola.; Chalmers University of Technology.; Göteborgs universitet.; Gothenburg University.; [1988]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : .... LÄS MER

  3. 3. Molecular characterization and evolution of alpha-actinin from protozoa to vertebrates

    Detta är en avhandling från Umeå : Kemi

    Författare :Ana Virel; Umeå universitet.; [2006]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; alpha-actinin; evolution; spectrin repeat; intragene duplication; phylogenetic tree; spectrin superfamily; NATURAL SCIENCES Chemistry Biochemistry; NATURVETENSKAP Kemi Biokemi;

    Sammanfattning : alpha-actinin is a ubiquitous protein found in most eukaryotic organisms. The ability to form dimers allows alpha-actinin to cross-link actin in different structures. In muscle cells alpha-actinin is found at the Z-disk of sarcomeres. LÄS MER

  4. 4. GDNF and alpha-synuclein in nigrostriatal degeneration

    Detta är en avhandling från Umeå : Umeå universitet

    Författare :Maria Chermenina; Umeå universitet.; [2014]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s disease; GDNF; ventral mesencephalon; lateral ganglionic eminence; alpha-synuclein; medicinsk utvecklings- och neurobiologi; Developmental Neurosciences;

    Sammanfattning : Parkinson’s disease is a common neurological disorder with a complex etiology. The disease is characterized by a progressive loss of dopaminergic cells in the substantia nigra, which leads to motor function and sometimes cognitive function disabilities. LÄS MER

  5. 5. Pathogenic effects of alpha-synuclein: modifications and toxicity

    Detta är en avhandling från Lund University, Faculty of Medicine

    Författare :Natalie Landeck; Lunds universitet.; Lund University.; [2016]
    Nyckelord :Parkinson s disease; adeno-associated viral vector; animal models; alpha-synuclein; substantia nigra; dopaminergic neurons; phosphorylation; aggregation; toxicity;

    Sammanfattning : Accumulation of intraneuronal inclusions, containing mainly a protein called alpha-synuclein (asyn), is thought to play a critical role in neurodegenerative disorders such as Parkinson's disease (PD). In these so called Lewy bodies, the majority of asyn is phosphorylated at serine 129 (pS129) suggesting that post-translational modifications may play a critical role in the process of aggregate formation. LÄS MER