Sökning: "Astrocyte"

Visar resultat 1 - 5 av 95 avhandlingar innehållade ordet Astrocyte.

  1. 1. Astrocyte metabolism following focal cerebral ischemia

    Författare :Anna E Thoren; Göteborgs universitet; []
    Nyckelord :Astrocyte; metabolism; focal cerebral ischemia; reperfusion; infarct; [1-14C]acetate; [U-14C]glucose; glutamine; glutamate; ATP; ADP; lactate; MCT4; immunogold cytochemistry;

    Sammanfattning : Stroke is one of the leading causes of disability and death. Most often, stroke results from blockage of an artery in the brain leading to tissue infarction within the perfusion territory of the affected vessel. LÄS MER

  3. 2. Role of Neuroinflammation in Parkinson's Disease and Related Disorders

    Författare :Edoardo Brandi; Neural plasticitet och reparation; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alpha synuclein; Preformed fibrils; Microglia; Astrocyte; Neuroinflammation; Lipopolysaccharides; Parkinson Disease; Lewy Body Dementia; Multiple system atrophy; Synucleinopathies;

    Sammanfattning : Synucleinopathies are neurodegenerative disorders characterized by intracellular protein aggregates, progressive neurodegeneration, and neuroinflammation. Alpha-synuclein (a-syn) is the principal component of intracellular aggregates and can be modified by several mutations and post-translational modifications (PTMs), which can alter the protein structure affecting its aggregation, toxicity, and ability to spread. LÄS MER

  4. 3. Astrocytic communication and cell death during metabolic depression and oxidative stress

    Författare :Christina Nodin; Göteborgs universitet; []
    Nyckelord :astrocyte; gap junction; ATP; ROS; oxidative stress; Annexin V; AIF; programmed cell death; Nrf2; scavenger; iodoacetate; SIN-1;

    Sammanfattning : Stroke is a major cause of death and adult disability in the western world. Most often, stroke is caused by the occlusion of a brain artery. Within the perfusion territory of the occluded vessel, various degrees of necrotic and delayed programmed cell death will occur if the occlusion persists, leading to expanding tissue damage. LÄS MER

  5. 4. Ethanol-mediated effects on astroglial cells in primary culture. With a focus on acute changes in intracellular Ca2+, cell volume, actin filaments, and gap junction coupling

    Författare :Louise Adermark; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; astrocyte; BaCl2; cell swelling; fura-2; furosemide; ouabain; scrape loading; volume estimation;

    Sammanfattning : The astroglial cells are abundant in the central nervous system (CNS), where they control and regulate the homeostasis of the extracellular milieu. A change in astroglial cell volume, mediated through activation of neuroactive substances or changes in osmolarity, leads to changes in the size and geometry of the extracellular space volume, which could affect the diffusion and concentration of neuroactive substances. LÄS MER

  7. 5. Ischemic Cell Death in the CNS - applications of a new in vitro model

    Författare :Tobias Cronberg; Sektion IV; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropsykologi; Neurologi; Neurology; astrocyte; stroke; adenosine; hyperglycaemia; glucose; free radicals; calcium; in vitro; brain ischemia; slice; neuropsychology; neurofysiologi; neurophysiology;

    Sammanfattning : Ischemic brain damage is a common cause of death and disability. A global ischemic insult is usually the result of a transient cardiac arrest while occlusion of cerebral blood vessels leads to focal ischemic lesions, commonly termed stroke. LÄS MER