Sökning: "SNARE"

Visar resultat 1 - 5 av 32 avhandlingar innehållade ordet SNARE.

  1. 1. Exocytosis in insulin secreting cells - role of SNARE-proteins

    Författare :Jenny Vikman; Diabetes - öcellsexocytos; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; calcium channel; cAMP; syntaxin 1; SNAP-25; SNARE; exocytosis; Insulin secretion; pancreatic beta-cells;

    Sammanfattning : Type 2 diabetes is marked by deterioration in pancreatic β-cell function. SNARE-proteins are crucial for the fusion of insulin granules with the plasma membrane, a prerequisite for insulin secretion. LÄS MER

  3. 2. Characterization of Physiological and Pathological Alpha-Synuclein : Implications for Parkinson’s Disease and Related Disorders

    Författare :Leire Almandoz Gil; Joakim Bergström; Martin Ingelsson; Kostas Vekrellis; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Alpha-synuclein; Aggregation; Parkinson’s disease; Dementia with Lewy bodies; Oxidative stress; Antibodies; Synapses; SNARE; Molekylär medicin; Molecular Medicine;

    Sammanfattning : Aggregated alpha-synuclein is the main component of Lewy bodies and Lewy neurites, intraneuronal inclusions found in the brains of Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) patients (synucleinopathies). Alpha-synuclein is a presynaptic protein, which is most commonly an unfolded monomer in its physiological state. LÄS MER

  4. 3. The assembly of cytosolic lipid droplets and its effect on insulin sensitivity

    Författare :Pontus Boström; Göteborgs universitet; []
    Nyckelord :diabetes; lipid metabolism; insulin resistance; lipid droplets; ADFP; SNARE;

    Sammanfattning : Accumulation of neutral lipids, in particular triglycerides, in non-adipocytes is highly related to the development of insulin resistance and its consequences, type-2 diabetes and cardiovascular diseases. The accumulation of triglycerides occurs in so-called lipid droplets in the cytosol. LÄS MER

  5. 4. Exocytosis in Type 2 Diabetes- Functional and genetic studies of hormone secretion

    Författare :Sofia A Andersson; Diabetes - öcellsexocytos; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 Diabetes; Insulin; Glucagon; Alpha-cells; Beta-cells; Exocytosis; Capacitance; SNARE; SNAP25; Syntaxin1A; Synaptotagmin; Munc-18 Stxbp1 ; SNP; Expression; miRNA;

    Sammanfattning : Type 2 Diabetes (T2D) is characterized by dysregulated beta-and alpha-cell hormone secretion leading to elevated blood glucose levels. Several proteins are crucial in maintaining exocytosis of the hormone-containing granules such as Syntaxin1A (Stx1A), SNAP25, Munc-18 (Stxbp1) and the family of Synaptotagmins (Syts). LÄS MER

  7. 5. On the mechanisms and physiological function of somatodendritic dopamine release in substantia nigra

    Författare :Filip Bergquist; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Calcium channels; dopamine release; microdialysis; rotarod; SNARE; striatum; substantia nigra;

    Sammanfattning : Somatodendritic release of neurotransmitters is a neuronal function that is poorly understood in comparison with the more abundant terminal release. This study aimed at characterising somatodendritic dopamine release in substantia nigra in terms of release mechanisms and possible physiological function in motor control. LÄS MER