Sökning: "Synapses"

Visar resultat 1 - 5 av 133 avhandlingar innehållade ordet Synapses.

  1. 1. On the Nature of β-Amyloid at Synapses

    Författare :Isak Martinsson; Experimentell demensforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; synapses; APP knockout; beta-Amyloid;

    Sammanfattning : Alzheimer’s disease is an aging related disorder of the mind, accountable for 60-80 percent of all cases of dementia. With its insidious progression and the decline of cognitive abilities, this disease is a major challenge for our society as a whole. LÄS MER

  3. 2. Characterization of Physiological and Pathological Alpha-Synuclein : Implications for Parkinson’s Disease and Related Disorders

    Författare :Leire Almandoz Gil; Joakim Bergström; Martin Ingelsson; Kostas Vekrellis; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Alpha-synuclein; Aggregation; Parkinson’s disease; Dementia with Lewy bodies; Oxidative stress; Antibodies; Synapses; SNARE; Molekylär medicin; Molecular Medicine;

    Sammanfattning : Aggregated alpha-synuclein is the main component of Lewy bodies and Lewy neurites, intraneuronal inclusions found in the brains of Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) patients (synucleinopathies). Alpha-synuclein is a presynaptic protein, which is most commonly an unfolded monomer in its physiological state. LÄS MER

  4. 3. Neuroinflammation and amyloid-β in early Alzheimer’s disease. Insight into the earliest events using mouse models

    Författare :Megg Gonzales Garcia; Neuroinflammation; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; amyloid-beta; neuroinflammation; microglia; synapses; prion-like;

    Sammanfattning : Alzheimer’s disease (AD) is the leading cause of dementia and most common neurodegenerative disease worldwide, but there currently exists no effective treatment that can stop nor slow the progression of the disease. The current dogma in the field postulates that the appearance of extracellular amyloid-beta (Aβ) plaques, a histopathological hallmark of the disease, is the trigger for downstream, detrimental events, including neuronal loss, extensive neuroinflammation and cognitive decline. LÄS MER

  5. 4. The synaptic and neurobiological role of apolipoprotein E4 in models of Alzheimer's disease

    Författare :Sabine Konings; Experimentell demensforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Apolipoprotein E4; Alzheimer s Disease; Synapses; Endosomes; β-amyloid; Neurons; Astrocytes;

    Sammanfattning : .... LÄS MER

  7. 5. Flexible Electrical and Photoelectrical Artificial Synapses for Neuromorphic Systems

    Författare :Kunlong Yang; Fernando Seoane; Li-rong Zheng; Juha Plosila; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Flexible electronics; Neuromorphic network; Memristor; Electron trapping; Electrical artificial synapse; Photoelectrical artificial synapse; Applied Medical Technology; Tillämpad medicinsk teknik;

    Sammanfattning : Over the past decade, the field of personal electronic systems has trended toward mobile and wearable devices. However, the capabilities of existing electronic systems are overwhelmed by the computing demands at the wearable sensing stage. Two main bottlenecks are encountered. LÄS MER