Sökning: "alpha"

Visar resultat 16 - 20 av 1299 avhandlingar innehållade ordet alpha.

  1. 16. Molecular studies on streptococcal surface proteins

    Författare :Johan Waldemarsson; Avdelningen för medicinsk mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nonimmunodominance; vaccine; camouflaging; Streptococcus agalactiae; leucine-rich repeat; Streptococcus pyogenes; alpha; fibrinogen; M protein; surface proteins; Rib;

    Sammanfattning : Streptococcus agalactiae and Streptococcus pyogenes are two related human pathogens causing different diseases. This thesis focuses on a number of surface proteins expressed by S. agalactiae and S. pyogenes and, more specifically, the molecular and biological characterization of these proteins. LÄS MER

  3. 17. Evolution of human alpha-herpesviruses

    Författare :Peter Norberg; Göteborgs universitet; []
    Nyckelord :HSV-1; HSV-2; VZV; evolution; recombination; phylogenetic analysis;

    Sammanfattning : Herpesviridae is a large virus family with more than 100 members, which are highly disseminated among animals. Three sub-families have been classified; alpha-herpesviruses, beta-herpesviruses and gamma-herpesviruses. LÄS MER

  4. 18. Signaling and regulation of cysteinyl leukotriene receptors in intestinal epithelial cells and colon cancer

    Författare :Astrid Bengtsson; Malmö Cellpatologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TNF alpha; COX-2; interferon alpha; all-trans retinoic acid; EGF; inflammation; colorectal cancer; CysLT2R; Leukotriene; CysLT1R;

    Sammanfattning : Colorectal cancer is the third most common type of cancer, and the second leading cause of cancer-related deaths in the Western world. Chronic inflammation, such as inflammatory bowel diseases (IBD), increases the risk of cancer. Cysteinyl leukotrienes are pro-inflammatory mediators that are involved in IBD. LÄS MER

  5. 19. Cellular interactions of HAMLET and their role in cell death

    Författare :Maria Trulsson; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HAMLET; alpha-lactalbumin; cancer; cell death; ion channels; p38; cell detachment; alpha-actinin; endocytosis; macropinocytosis; c-Myc; glycolysis;

    Sammanfattning : HAMLET is a protein-lipid complex that selectively kills tumor cells. In this thesis, we identified new mechanisms, whereby HAMLET initiates and executes tumor cell death. HAMLET targets several cellular compartments ranging from the plasma membrane to the nucleus. LÄS MER

  7. 20. Hypoxia inducible factor 1 alpha : dependent and independent regulation of hematopoietic stem cells and leukemia

    Författare :Camilla Halvarsson; Jan-Ingvar Jönsson; Mikael Sigvardsson; Kamil Kranc; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : This thesis has studied the role of low oxygen levels, or hypoxia, in hematopoietic stem cells (HSCs) and how, at the molecular level, it regulates stem cell maintenance and protects against oxidative stress induced by reactive oxygen species (ROS). HSCs reside within the bone marrow in specific niches created by a unique vascularized environment, which is suggested to be hypoxic and crucial for HSCs by maintaining a quiescent state of cell cycle and by redirecting metabolism away from the mitochondria to glycolysis. LÄS MER