Sökning: "Lena Claesson-Welsh"

Visar resultat 1 - 5 av 17 avhandlingar innehållade orden Lena Claesson-Welsh.

1. 1. Molecular Regulation of Inflammation and Angiogenesis in the Tumor Microenvironment

   Författare :Lothar Dieterich; Anna Dimberg; Lena Claesson-Welsh; Jonas Fuxe; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; stroma; glioma; alphaB-crystallin; HSPB5; cryab; myeloid cells; Morphology; cell biology; pathology; Morfologi; cellbiologi; patologi; Cell and molecular biology; Cell- och molekylärbiologi; Molekylär medicin; Molecular Medicine;

   Sammanfattning : Tumor growth and progression not only depend on properties of the malignant cells but are strongly influenced by the tumor microenvironment. The tumor stroma consists of various cell types such as inflammatory cells, endothelial cells and fibroblasts, which can either inhibit or promote tumor growth. LÄS MER

3. 2. VEGFR-2 in Endothelial Differentiation and Vascular Organization

   Författare :Dan Edholm; Lena Claesson-Welsh; Xiujuan Li; Victoria Bautch; Uppsala universitet; []
   Nyckelord :Molecular medicine; Embryonic stem; VEGFR-2; Flk1; KDR; VEGF; vasculogenesis; angiogenesis; embryoid body; Molekylärmedicin;

   Sammanfattning : The cardiovascular system is the first functional organ to develop during embryogenesis. As the embryo reaches above a certain size, passive diffusion of gases and nutrients is no longer compatible with efficient growth. LÄS MER

4. 3. Altered proteins in the aging brain

   Författare :Adila Elobeid; Irina Alafuzoff; Lena Claesson-Welsh; Thomas Brännström; Uppsala universitet; []
   Nyckelord :Cognitively unimpaired subjects; Hyperphosphorylated tau; Beta amyloid; Alpha-synclein; Transactive response DNA binding protein 43; Patologi; Pathology;

   Sammanfattning : The classification of neurodegenerative disorders is based on the major component of the protein aggregates in the brain. The most common altered proteins associated with neurodegeneration are Hyperphosphorylated tau (HPt), beta amyloid (Aβ), alpha-synclein (αS) and transactive response DNA binding protein 43 (TDP43). LÄS MER

5. 4. Vascular targeting for enhanced cancer immunotherapy

   Författare :Maria Georganaki; Anna Dimberg; Sara Mangsbo; Lena Claesson-Welsh; Wolf Hervé Fridman; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer immunotherapy; tumor vasculature; endothelial activation; IDO1; ELTD1; tertiary lymphoid organ; Biologi; Biology;

   Sammanfattning : Induced angiogenesis and chronic inflammation are major components of tumor immunosuppression. The scope of this thesis is to understand the role of the vasculature in anti-tumor immunity and thereby to improve cancer immunotherapy. LÄS MER

7. 5. Modulation of Angiogenesis by Laminins and Heparan Sulfate

   Författare :Lars Jakobsson; Lena Claesson-Welsh; Johan Kreuger; Elisabetta Dejana; Uppsala universitet; []
   Nyckelord :Molecular medicine; Embryonic stem; heparan sulfate; laminin; basement membrane; VEGFR-2; VEGF; endothelial cell; signaling; angiogenesis; vasculogenesis; embryoid body; Molekylärmedicin;

   Sammanfattning : Blood vessels transport blood with essential nutrients and oxygen to the cells in our body. In a healthy adult, formation of new vessels (angiogenesis) occurs only in case of tissue repair and growth. LÄS MER