Sökning: "heparan sulfate"

Visar resultat 1 - 5 av 98 avhandlingar innehållade orden heparan sulfate.

  1. 1. Decoding Heparan Sulfate

    Författare :Johan Kreuger; John T. Gallager; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Heparan sulfate; fibroblast growth factor; receptor; endostatin; angiogenesis; interaction; sequence; Biokemi; Biochemistry; Biokemi; Medical Biochemistry; medicinsk biokemi;

    Sammanfattning : Heparan sulfate (HS) is a polysaccharide of glycosaminoglycan type composed of alternating hexuronic acid [either glucuronic acid (GlcA) or iduronic acid (IdoA)] and glucosamine (GlcN) units that can be sulfated in various positions. HS binds to a large number of proteins and these interactions promote many biological processes, including cell adhesion and growth factor signaling. LÄS MER

  3. 2. Functions of Heparan Sulfate During Mouse Development : Studies of Mice with Genetically Altered Heparan Sulfate Biosynthesis

    Författare :Maria Ringvall; Lena Kjellén; Erik Forsberg; Ulf Lindahl; Erika Gustafsson; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; embryonic development; gene targeting; lung development; ossification; heparan sulfate; heparin; N-deacetylase N-sulfaotransferase; NDST; proteoglycan; morphogen; biosynthesis; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi;

    Sammanfattning : Heparan sulfate (HS) is a ubiquitous polysaccharide on the cell surface and in the extracellular matrix. HS is an important actor in the regulation of cell signaling, especially in the developing embryo. LÄS MER

  4. 3. Heparan Sulfate and Development : A Study of NDST Deficient Mice and Embryonic Stem Cells

    Författare :Katarina Holmborn; Lena Kjellén; Erik Forsberg; Catherine L. Merry; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell and molecular biology; heparan sulfate; proteoglycan; biosynthesis; N-deacetylase N-sulfotransferase; NDST; gene targeting; embryonic development; lung development; mast cells; Cell- och molekylärbiologi;

    Sammanfattning : Heparan sulfate (HS) proteoglycans consist of sulfated HS chains covalently bound to core proteins. They are ubiquitously expressed, on the cell surface and in the extracellular matrix, throughout the body. LÄS MER

  5. 4. Cellular design of heparan sulfate : The NDST enzymes and their regulation

    Författare :Pernilla Carlsson; Lena Kjellén; Tarja Kinnunen; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; heparan sulfate; heparin; proteoglycan; NDST; PAPS; Golgi; Cell and molecular biology; Cell- och molekylärbiologi;

    Sammanfattning : Heparan sulfate proteoglycans are proteins with long, unbranched heparan sulfate (HS) polysaccharide chains attached to them. They are found on cell surfaces and in basement membranes where they exert their action by interacting with a wide range of enzymes and signaling molecules and are thereby involved in a range of various processes both during embryonic development and in adult physiology. LÄS MER

  7. 5. Protein recognition domains in heparan sulfate

    Författare :Emadoldin Feyzi Talarposhti; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; heparan sulfate; heparin; structure; growth factors; herpes simplex virus; antithrombin; aging; regulation; Biokemi; Biochemistry; Biokemi; Medical and Physiological Chemistry; medicinsk och fysiologisk kemi;

    Sammanfattning : Heparan sulfate (HS) is a sulfated glycosaminoglycan (GAG) implicated in various physiological and pathological processes such as cell proliferation, viral infection and inhibition of blood coagulation. These effects are due to interactions of HS with proteins. LÄS MER