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Visar resultat 11 - 15 av 37 avhandlingar som matchar ovanstående sökkriterier.

  1. 11. Developing and democratizing tools for spatially resolved profiling of genome and transcriptome

    Författare :Eleni Gelali; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The common thread of the work presented in this thesis is the development and democratization of tools that facilitate the spatial profiling of genome and transcriptome. Paper I describes iFISH, a resource that facilitates the large-scale design and costeffective, flexible production of probes for DNA FISH. LÄS MER

  3. 12. Interpreting the human transcriptome

    Författare :Beata Werne Solnestam; Joakim Lundeberg; Piero Carninci; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Transcriptome; RNA sequencing; high-throughput sequencing; gene expression profiling; multiplex amplification; Bioteknologi; Biotechnology;

    Sammanfattning : The human body is made of billions of cells and nearly all have the same genome. However, there is a high diversity of cells, resulted from what part of the genome the cells use, i.e. which RNA molecules are expressed. LÄS MER

  4. 13. Transcriptional patterns in inflammatory disease

    Författare :Johan Lindberg; Joakim Lundeberg; Eivind Hovig; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Gene expression profiling; transcription; microarray; rheumatoid arthritis; synovial tissue; variability; TNF‐α; anti‐TNF treatment; periodontitis; PGE2; Bioengineering; Bioteknik;

    Sammanfattning : In the studies this thesis is based upon, microarrays were applied to profilemRNA populations in biological samples to gain insights into transcriptionalpatterns and their relation to inflammatory disease.Rheumatoid arthritis (RA) is a chronic inflammatory disease, which leads todegradation of cartilage and bone. LÄS MER

  5. 14. Mining the transcriptome - methods and applications

    Författare :Valtteri Wirta; Joakim Lundeberg; John Quackenbush; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; transcriptome; gene expression profiling; EST; microarray; RNA amplification; stem cells; neurosphere; Genetic engineering including functional genomics; Genteknik inkl. funktionsgenomik;

    Sammanfattning : Regulation of gene expression occupies a central role in the control of the flow of genetic information from genes to proteins. Regulatory events on multiple levels ensure that the majority of the genes are expressed under controlled circumstances to yield temporally controlled, cell and tissue-specific expression patterns. LÄS MER

  7. 15. Intrinsic and extrinsic mechanisms for B-cell lymphoma development and progression studied by global gene expression profiling

    Författare :Gustav Arvidsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mantle cell lymphoma (MCL) is a rare hematopoietic malignancy characterized by frequent relapses and poor survival, partly due to minimal residual disease, whereby a subset of malignant cells, harbored in protective niches, survive treatment. In vitro and ex vivo experiments have shown that MCL cells can be rescued from apoptosis through interactions with non- malignant cells such as stromal cells. LÄS MER