Sökning: "thioflavin-T"

Visar resultat 16 - 17 av 17 avhandlingar innehållade ordet thioflavin-T.

1. 16. Luminescent molecular recognition of pathognomonic and aging associated protein aggregates

   Författare :Daniel Sjölander; Per Hammarström; Peter Nilsson; Uno Carlsson; Jan Johansson; Linköpings universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : Various protein inclusions have been recognized to be associated with aging and pathogenic conditions, such as in Alzheimer’s disease, Parkinson’s disease, Type 2 diabetes, and the prionoses Creutzfeldt-Jakob disease, Chronic wasting disease (CWD), and Mad cow disease. The causative transition of protein aggregation is the alteration in the conformation of the protein that renders the protein susceptible towards self-assembly. LÄS MER

3. 17. Characterization of the Alzheimer's disease-associated clac protein

   Författare :Linda Söderberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Alzheimer's disease (AD) is the most prevalent form of dementia in elderly people and is neuropathologically characterized by the presence of extracellular senile plaques (SPs) in the brain. SPs are mainly composed of the amyloid beta-peptide (Abeta), proteolytically derived from the amyloid beta-precursor protein by sequential cleavages performed by beta- and gammasecretase, to generate Abeta species of 40 and 42 amino acids, respectively. LÄS MER