Sökning: "systemic sclerosis"

Visar resultat 16 - 20 av 53 avhandlingar innehållade orden systemic sclerosis.

  1. 16. CNS-Targeted Cell Therapy for Multiple Sclerosis

    Författare :Moa Fransson; Angelica Loskog; Tomas Olsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CAR; Targeting; Suppressive cells; Foxp3; Tregs; Clinical immunology; Klinisk immunologi; Immunologi; Immunology;

    Sammanfattning : Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system (CNS). In the current thesis, we have preformed an immunological investigation of patients with MS and developed an immunosuppressive cell therapy that could be beneficial for these patients. LÄS MER

  3. 17. Investigation of genetic factors in multiple sclerosis

    Författare :Izaura Lima Bomfim; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Multiple sclerosis (MS) is a chronic disease where the transmission of signals in the central nervous system is affected leading to a broad range of symptoms. The aetiology of the disease is unknown but multiple genetic and environmental factors are believed to play a part. LÄS MER

  4. 18. Immunological Mechanisms and Natalizumab Treatment in Multiple Sclerosis : Studies on lymphocytes, inflammatory markers and magnetic resonance spectroscopy

    Författare :Johan Mellergård; Magnus Vrethem; Jan Ernerudh; Charlotte Dahle; Sten Fredrikson; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : Background: Multiple sclerosis (MS) is a chronic inflammatory, demyelinating disease of the central nervous system (CNS), and a frequent cause of neurological disability among young adults. In addition to focal inflammatory demyelinated lesions, diffuse white matter pathology as well as a neurodegenerative component with accumulating axonal damage and gliosis have been demonstrated and contribute to MS disease characteristics. LÄS MER

  5. 19. Immunity and inflammation in amyotrophic lateral sclerosis : an epidemiological approach

    Författare :Can Cui; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Amyotrophic lateral sclerosis (ALS) is a rare but lethal neurodegenerative disease, characterized by degeneration of both upper and lower motor neurons in the brain and spinal cord. The pathogenesis of ALS is, however, not completely clear. LÄS MER

  7. 20. Matrix-degrading metalloproteinases and cytokines in multiple sclerosis and ischemic stroke

    Författare :Mathilde Cornelia Maria Kouwenhoven; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by blood-brain barrier breakdown, perivascular inflammation and demyelination. In ischemic stroke, an inflammatory reaction develops shortly after arterial occlusion. LÄS MER