Avancerad sökning

Hittade 5 avhandlingar som matchar ovanstående sökkriterier.

1. 1. A Surface Phase Model of the Alveolar Lining: Ultrastructural Analysis and in vivo Applications

   Författare :Marcus Larsson; Lund Pediatrik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; X-ray diffraction; cryo-TEM; dynamic swelling; ARDS; surface phase; surfactant replacement therapy; cholesterol; minimal surface; pulmonary surfactant; alveolar surface; Physiology; Fysiologi;

   Sammanfattning : In this thesis the relation between lung surfactant structure and functional properties have been studied. Experimental results show that the alveolar surface is formed by a coherent surface phase with a structure equal to tubular myelin. The properties of this phase may explain certain unresolved issues in lung physiology, e.g. LÄS MER

3. 2. Respiratory distress syndrome aspects of inhaled nitric oxide, surfactant and nasal CPAP

   Författare :Robert B I Lindwall; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Nitric oxide; Nitrogen dioxide; Pulmonary surfactants; Respiratory therapy; Inhalation exposure; Administration; Inhalation; Continuous Positive Airway Pressure;

   Sammanfattning : Respiratory distress syndrome (RDS) still represents one of the main problems in the treatment of premature infants. Despite the use of surfactant replacement therapy RDS adds to the need for endotracheal intubation and mechanical ventilation (M). LÄS MER

4. 3. Surfactant treatment in neonatal group B streptococcal pneumonia : experimental and clinical studies

   Författare :Egbert Herting; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Surfactant dysfunction is probably involved in the pathophysiology of neonatal group B streptococcal (GBS) pneumonia. Aim of the present studies was to evaluate efficacy and safety of surfactant replacement therapy for term and preterm neonates with severe respiratory failure due to GBS infection. LÄS MER

5. 4. Development of novel synthetic lung surfactants for treatment of respiratory distress syndrome

   Författare :Oihana Basabe Burgos; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Pulmonary surfactant is a complex mixture of lipids and specific proteins found in the alveoli and its main role is to reduce the surface tension of the alveolar air/water interface, thereby preventing lung collapse. Lack of pulmonary surfactant in premature babies results in lethal respiratory distress syndrome (RDS), which is today treated with surfactant replacement therapy, i. LÄS MER

7. 5. Bronchopulmonary dysplasia from newborn disease to long-term sequelae

   Författare :Eva Berggren Broström; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Bronchopulmonary Dysplasia (BPD) is a complication of premature birth that is associated with increased mortality and morbidity in infancy and impaired lung function and obstructive lung disease from childhood to adulthood. The pathogenesis of BPD is multifactorial, and may involve one or more of the following: a deficiency in surfactant production in the immature lung, chronic inflammatory processes before and after birth, oxidative stress, and trauma due to mechanical ventilation. LÄS MER