Sökning: "small molecule"

Visar resultat 6 - 10 av 524 avhandlingar innehållade orden small molecule.

  1. 6. Small-molecule layers for devices –Evaporation growth

    Författare :Måns Andreasson; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY;

    Sammanfattning : .... LÄS MER

  3. 7. Chemical attenuation of bacterial virulence : small molecule inhibitors of type III secretion

    Författare :Anna Kauppi; Mikael Elofsson; Anders Karlén; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; antibiotic resistance; virulence; type III secretion; T3SS inhibitors; Yop; SMD; QSAR; screening; Yersinia pseudotuberculosis; Organic chemistry; Organisk kemi;

    Sammanfattning : Despite the large arsenal of antibiotics available on the market, treatment of bacterial infections becomes more challenging in view of the fact that microbes develop resistance against existing drugs. There is an obvious need for novel drugs acting on both old and new targets in bacteria. LÄS MER

  4. 8. Small-Molecule Galectin Inhibitors - On Tweezers and Talosides

    Författare :Christopher Öberg; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Abstract Work on the design, synthesis, and biological evaluation of galectin inhibitors is presented. The most significant results relate to the development of galactose-based arginine “tweezers” and taloside-based galectin inhibitors. The galectins are a β-galactoside binding protein family. LÄS MER

  5. 9. Shedding light on the STAT3 small molecule inhibitor field

    Författare :Sander Busker; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : STAT3 is one of the seven family members of the STAT transcription factor family. STAT3 has become a very attractive target for cancer therapy and other diseases. It has a prominent role in cancer development as well as progression. However, there are still no STAT3 inhibitors applied in the clinic. LÄS MER

  7. 10. p53 reactivation by the small molecule RITA : molecular mechanisms

    Författare :Vera Grinkevich; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Inactivation of the tumor suppressor p53 is essential for the development and maintenance of cancer cells. Therefore, reactivation of p53 appears to be a promising strategy for anti-cancer therapy. LÄS MER