Sökning: "single nucleotide polymorphisms"

Visar resultat 31 - 35 av 220 avhandlingar innehållade orden single nucleotide polymorphisms.

  1. 31. Long chain polyunsaturated fatty acids in serum phospholipids - relation to genetic polymorphisms, diet and allergy development in children

    Författare :Malin Barman; Chalmers tekniska högskola; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cord serum; ELOVL; Polyunsaturated fatty acids; FADS; allergy; vitamin D;

    Sammanfattning : Polyunsaturated fatty acids (PUFAs) are essential for human cell and tissue development. In foetus, PUFAs are supplied via placental transfer from maternal circulation. After birth, PUFAs are supplied via the diet. Long chain PUFAs (LCPUFAs) may also be synthesized from precursor fatty acids present in the diet. LÄS MER

  3. 32. Identification of susceptibility genes in type 2 diabetes

    Författare :Sofia Nordman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Type 2 diabetes; single nucleotide polymorphism; genetic association;

    Sammanfattning : Identification of the susceptibility genes will offer better understanding of molecular mechanisms underlying T2D pathogenesis, and subsequently may lead to development of novel therapeutic approaches. This thesis mainly concerns the genetic association study of four candidate genes. LÄS MER

  4. 33. Using SNPs to study complex genetic disease : a population and evolutionary genetics perspective

    Författare :Sara Lynn Sawyer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Single nucleotide polymorphisms; population genetics; natural selection; genetic variation; haplotypes; linkage disequilibrium; genotyping methods;

    Sammanfattning : Associating genes to complex genetic diseases has proven more difficult than anticipated. Many genetic variants contribute small effects towards an individual's disease predisposition in polygenic diseases, and this biological complexity requires new methods of analysis. LÄS MER

  5. 34. Identification of the susceptibility genes in type 1 diabetes and diabetic nephropathy

    Författare :Jun Ma; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Type 1 Diabetes; Diabetic Nephropathy; Genetic Association; Single Nucleotide Polymorphism;

    Sammanfattning : Genetic susceptibility plays an important role in the pathogenesis of type 1 diabetes (T1D) and diabetic nephropathy (DN). The present study aims to investigate the association between single nucleotide polymorphisms (SNPs) in candidate genes and DN. LÄS MER

  7. 35. Genetic and functional analyses of diabetic nephropathy with focus on chromosome 3q

    Författare :Dongying Zhang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Diabetic nephropathy; chromosome 3; single nucleotide polymorphism; genetic association; gene expression;

    Sammanfattning : Diabetic nephropathy (DN) is a complex disease affected by both genetic and environmental factors. Genetic and functional analyses of the susceptibility and/or resistance genes in DN may provide useful information for better understanding the pathogenesis and further developing novel therapeutic approaches in this disease. LÄS MER