Avancerad sökning

Hittade 4 avhandlingar som matchar ovanstående sökkriterier.

1. 1. The significance of placental and placental-like alkaline phosphatases in tumor biology and their potential use in clinical practice

   Författare :Annika Jeppsson; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Alkaline phosphatase; seminoma; eutopic; gynaecological tumors; immunolocalization;

   Sammanfattning : Placental alkaline phosphatase (PLAP) is a membrane bound enzyme normally synthesized by the syncytiotrophoblasts in the human placenta. Recent studies have indicated that trace amounts of placental-like alkaline phosphatases also are present in several normal organs like testes and endocervix. LÄS MER

3. 2. Etiological insights into the testicular cancer epidemic

   Författare :Olof Akre; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Testicular neoplasms; seminoma; nonseminoma; epidemiology; etiology; risk factors; prenatal; fertility; birth weight; placenta; neonatal jaundice; cryptorchidism; hypospadias; preterm birth; Epstein-Barr virus; cytomegalovirus; Body Mass Index; height;

   Sammanfattning : The aim of this thesis was to search for causes of the testicular cancer epidemic through epidemiologic studies of testicular cancer and possibly related conditions, such as urogenital birth defects and subfertility. First, we assessed changes in fertility over time by studying time-to-pregnancy among primiparous women in Sweden from 1983 through 1993 using data from the Medical Birth Registry. LÄS MER

4. 3. Molecular epidemiology of complex heritable disease : applications in genomics and metabolomics

   Författare :Robert Karlsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Modern high-throughput molecular technologies (collectively referred to as “omic” platforms) are generating unprecedented amounts of data on human variation. The four papers in this thesis each investigate and characterize associations between common, complex, heritable disease, and genetic or metabolomic markers from omic platforms. LÄS MER

5. 4. Human intestinal alkaline phosphatase : tissue expression and serum levels

   Författare :Ulla Domar; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Human alkaline phosphatase; intestinal alkaline phosphatase; blood; blood group; lipid; monoclonal antibody; immunohistochemistry; liver; kidney; pancreas; liver disease; inflammatory bowel disease;

   Sammanfattning : Human alkaline phosphatase (ALP) comprises four isozymes, viz liver/bone/ kidney or tissue unspecific (AP), intestinal (LAP), placental (PLAP) and germ cell or PLAP-like alkaline phosphatase, with their main expression in specific tissues as indicated by their names. The isozymes are coded by different genes, but they are closely related, with more than 50% amino acid sequence homologies. LÄS MER