Sökning: "scavenger receptor a"

Visar resultat 11 - 15 av 48 avhandlingar innehållade orden scavenger receptor a.

1. 11. Structural and functional studies of class A scavenger receptors MARCO (SCARA2) and SCARA5

   Författare :Juha Ojala; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Our bodies are constantly exposed to various microorganisms and there is a constant battle between their survival and ours. Fortunately we are equipped with our immune system that takes remarkably good care of us, but when it fails we all know the consequences. LÄS MER

3. 12. Cell-penetrating peptides : an uptake mechanism & a new endosomolytic peptide

   Författare :Henrik Helmfors; Ülo Langel; Andreas Barth; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cell-penetrating peptides; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Sammanfattning : Peptide-based drugs have slowly begun migrating from laboratories into pharmacies and now there are several on the market. However, currently only one gene based therapy that is relies on a viral delivery vector has been approved. LÄS MER

4. 13. Megalin, an Endocytotic Receptor with Signalling Potential

   Författare :Mårten Larsson; Lars Rask; Bo Åkerström; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Megalin; LRP-2; Postsynaptic density-95; Retinol-binding protein; Oligodendrocytes; Central nervous system; Biokemi; Biochemistry; Biokemi;

   Sammanfattning : Megalin is an endocytotic receptor belonging to the low-density lipoprotein family. It has often been viewed only as merely a scavenger receptor of absorptive and secretory epithelia. Recent work has revealed that the megalin intracellular domain contains several motifs potentially binding proteins involved in signal transduction. LÄS MER

5. 14. Cell-penetrating peptides and oligonucleotides : Design, uptake and therapeutic applications

   Författare :Andrés Muñoz-Alarcón; Ülo Langel; Sandrine Sagan; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell-penetrating peptides; oligonucleotides; scavenger receptors; telomerase; gene therapy; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Sammanfattning : Regulation of biological processes through the use of genetic elements is a central part of biological research and also holds great promise for future therapeutic applications. Oligonucleotides comprise a class of versatile biomolecules capable of modulating gene regulation. LÄS MER

7. 15. Cell-penetrating peptides; chemical modification, mechanism of uptake and formulation development

   Författare :Kariem Ezzat; Ülo Langel; Steven Dowdy; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cell penetrating peptides; gene therapy; scavenger receptors; pharmaceutical formulation; solid dispersion; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Sammanfattning : Gene therapy holds the promise of revolutionizing the way we treat diseases. By using recombinant DNA and oligonucleotides (ONs), gene functions can be restored, altered or silenced according to the therapeutic need. LÄS MER