Sökning: "scavenger receptor a"

Visar resultat 16 - 20 av 48 avhandlingar innehållade orden scavenger receptor a.

  1. 16. Revealing the secrets of MARCO : a target for cancer immunotherapy

    Författare :Silke Eisinger; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Our immune system protects us from infectious agents and sustains the homeostasis in our body. However, the immune system can also play a role in initiation and progression of diseases such as autoimmune diseases and cancer. Cancer is still one of the leading causes for death worldwide and inflammation became one of the hallmarks of cancer. LÄS MER

  3. 17. Protein tyrosine phosphatases : taking a 'redoxionist' look at PDGFR signaling

    Författare :Jeroen Frijhoff; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Protein Tyrosine Phosphatases (PTPs) are oxidized and inactivated by reactive oxygen species (ROS) upon stimulation of a wide range of cell surface receptors, including the platelet-derived growth factor (PDGF) receptor (PDGF R). Signaling via this receptor tyrosine kinase stimulates cell proliferation and migration, and it is associated with cancer and cardiovascular diseases. LÄS MER

  4. 18. Decoding the tumor microenvironment : a B-cell and macrophage perspective

    Författare :Vanessa F Boura; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The immune system plays a role in many different functions in our body, and disease is no exception. Cancer is one of the biggest challenges of the twenty first century and vast efforts have been made to understand this disease. LÄS MER

  5. 19. Design and synthesis of steroid mimetic libraries using solid phase techniques

    Författare :Marcus Ruda; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Pyridone; quinolone; benzoindazole; solid phase chemistry; scavenger resin; combinatorial chemistry; alpha-arylation; nuclear hormone receptor; steroid mimetic.;

    Sammanfattning : This thesis deals with the design and synthesis of biologically active ligands for nuclear hormone receptors using combinatorial techniques. In the first part, a 5,6,6a,7,8,9,10,10a-octahydrobenzo[f]quinolin-3(4H)-one tricyclic core structure was designed mimicking the ABC-rings of a steroid. LÄS MER

  7. 20. The influence of quartz and surfactant on immune responses

    Författare :Göran Zetterberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :alveolar macrophages; complement receptor 1 and 3; interstitial macrophages; Iysophosphatidylcholine; phospholipids; quartz; rats; receptor expression; surfactant.;

    Sammanfattning : Pulmonary surfactant is a mixture of lipids and proteins that embeds the alveolar cells, has surface tension reducing properties but also influences the immune response. To further investigate this, quartz was used to initiate an inflammatory response in two different models. LÄS MER