Sökning: "rat hippocampus"

Visar resultat 1 - 5 av 138 avhandlingar innehållade orden rat hippocampus.

  1. 1. Differential effects of voluntary running on hippocampal plasticity in the adult rat brain

    Författare :Andrew Stuart Naylor; Göteborgs universitet; []
    Nyckelord :exercise; hippocampus; stress; progenitor proliferation; neurogenesis; trophic factors; frontal cortex; spatial memory; rat; pCREB; endogenous opioids;

    Sammanfattning : The continuation of neuronal birth from dividing neural stem cells in the dentate gyrus of the hippocampus throughout adulthood is known to play an important role in maintaining normal hippocampal function, such as memory and learning. Negative alterations in the levels of adult neurogenesis have also been linked to several neurodegenerative diseases, including Alzheimer s disease and mood disorders such as depression. LÄS MER

  3. 2. Opioids regulate proliferation of neural progenitors. A study on the effects of opioids on adult rat hippocampal progenitors in vitro and in vivo

    Författare :Anders I. Persson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Opioid; brain; hippocampus; rat; neurogenesis; progenitor; stem cell; b-endorphin; calcium; MAPK;

    Sammanfattning : The opioid receptors were among the first pharmacologically described brain receptors. These opioid receptors have thereafter been shown to mediate effects on proliferation and differentiation in both the embryonal and adult central nervous system. LÄS MER

  4. 3. New neurons and astrocytes in the adult brain. Studies on adult rat neural progenitors in vivo and in vitro with special reference to the effects of IGF-I and CNTF regarding proliferation and lineage determination

    Författare :Maria A I Åberg; Göteborgs universitet; []
    Nyckelord :Brain; hippocampus; rat; neurogenesis; progenitor cell; stem cell; ciliary neurotrophic factor; insulin-like growth factor-I; PI3-K; MAPK.;

    Sammanfattning : The hippocampal dentate gyrus in several species, including man, continues to produce new neurons and glial cells in adulthood. The generation of new neurons and glial cells in the adult hippocampus is under strict regulation. Two major events of significance for cell genesis from progenitor cells are proliferation and lineage determination. LÄS MER

  5. 4. Brain Regeneration - in vitro and in vivo studies of exercise-related effects on brain plasticity

    Författare :Cecilia Bull; Göteborgs universitet; []
    Nyckelord :brain; neural progenitor cells; stem cells; hippocampus; corpus collosum; rat; mouse; regeneration; neurogenesis; oligodendrogenesis; irradiation; exercise;

    Sammanfattning : Neural stem and progenitor cells in the germinal regions of the adult brain, such as the hippocampus, are of great interest, because they provide the possibility for enhanced brain plasticity or can contribute to endogenous cell replacement after injury or disease. Voluntary exercise was recently shown to robustly induce cellular and structural plasticity, thereby contributing to overall brain health. LÄS MER

  7. 5. GH/IGF-I axis regulation of cardiovascular and neuronal gene expression and function

    Författare :Anna Barlind; Göteborgs universitet; []
    Nyckelord :Growth hormone; rat; hypophysectomy; vascular resistance; gene expression; place learning; Intellicage; hexarelin; CNS; hippocampus; neurogenesis; cell survival; mouse;

    Sammanfattning : Abstract Cardiovascular disease is a major cause of mortality in the Western world. Another important clinical condition is brain damage due to radiation therapy in cancer patients. This has neurological impairments presenting in the survivors. For both these conditions, it is important to develop new therapeutic strategies. LÄS MER