Sökning: "proliferation resistance"

Visar resultat 21 - 25 av 193 avhandlingar innehållade orden proliferation resistance.

  1. 21. Oxidant-induced cell death in lymphocytes: mechanisms of induction and resistance

    Författare :Fredrik Bergh Thorén; Göteborgs universitet; []
    Nyckelord :reactive oxygen species; cell death; apoptosis; poly ADP-ribose polymerase-1; apoptosis-inducing factor; natural killer cells; phagocytes; dendritic cells;

    Sammanfattning : Reactive oxygen species (oxidants, oxygen radicals) produced by the phagocytic NADPH oxidase have pivotal roles in immunity. Patients lacking a functional NADPH oxidase suffer from chronic granulomatous disease, which is characterized by recurring bacterial infections and thus manifesting the importance of reactive oxygen species in host defense against bacteria. LÄS MER

  3. 22. Molecular mechanisms of imatinib resistance in gastrointestinal stromal tumor with focus on microRNAs

    Författare :Pınar Akçakaya; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Gastrointestinal stromal tumor (GIST) is mainly initialized by mutations in receptor tyrosine kinase genes KIT or PDGFRA. The development of imatinib, a small molecule inhibitor that targets these tyrosine kinase receptors, remarkably improved patient outcome. LÄS MER

  4. 23. Mechanisms of multicellular drug resistance and novel approaches for targeted therapy in cancer

    Författare :Elin Edsbäcker; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Dysregulated gene expression, due to genetic and epigenetic aberrations, as well as cancer cell-stroma interactions underlie both tumorigenesis and resistance to anti-cancer therapy. Although governed by common mechanisms, these features are unique to each individual tumor and therefore a personalized treatment regimen needs to be composed for each patient. LÄS MER

  5. 24. Exposure to xenobiotic chemicals disrupts metabolism, rhythmicity and cell proliferation in Drosophila melanogaster

    Författare :Hao Cao; Helgi B. Schiöth; Michael J. Williams; Jan Larsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; xenobiotics; metabolism; insulin signalling; circadian rhythm; carcinogen; Biomedical Laboratory Science; Biomedicinsk laboratorievetenskap;

    Sammanfattning : Most species are constantly exposed to xenobiotic chemicals through multiple routes. Among all categories of xenobiotics, phthalates and bisphenols are two of the most widely used plasticizers and can be found in polyvinyl chloride (PVC) materials, medical devices and even drinking water. LÄS MER

  7. 25. From oncogenic replication stress to drug resistance : F-box proteins as signalling hubs in cancer

    Författare :Andrä Brunner; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cancer arises from cells that acquire genetic and epigenetic changes during the course of a, sometimes decades-long, somatic evolutionary process. These changes result in deregulation of a multitude of cellular processes leading to novel capabilities, often referred to as hallmarks of cancer, and a strong selective advantage for these cells albeit at a dramatic cost to the organism as a whole. LÄS MER