Sökning: "potentiation"

Visar resultat 21 - 25 av 84 avhandlingar innehållade ordet potentiation.

  1. 21. Neurotransmission and functional synaptic plasticity in the rat medial preoptic nucleus

    Författare :Evgenya Malinina; Staffan Johansson; Eric Hanse; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; medial preoptic nucleus; synaptic plasticity; GABA; glutamate; L-type Ca2 channel; Physiology; Fysiologi; fysiologi; Physiology;

    Sammanfattning : Brain function implies complex information processing in neuronal circuits, critically dependent on the molecular machinery that enables signal transmission across synaptic contacts between neurons. The types of ion channels and receptors in the neuronal membranes vary with neuron types and brain regions and determine whether neuronal responses will be excitatory or inhibitory and often allow for functional synaptic plasticity which is thought to be the basis for much of the adaptability of the nervous system and for our ability to learn and store memories. LÄS MER

  2. 22. On the Mechanisms Behind Hippocampal Theta Oscillations : The role of OLMα2 interneurons

    Författare :Sanja Mikulovic; Richardson Leao; Klas Kullander; Stefan Remy; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hippocampus; interneuron; optogenetics; theta oscillations; anxiety;

    Sammanfattning : Theta activity is one of the most prominent rhythms in the brain and appears to be conserved among mammals.  These 4-12 Hz oscillations have been predominantly studied in the dorsal hippocampus where they are correlated with a broad range of voluntary and exploratory behaviors. LÄS MER

  3. 23. Mechanism of pure glucose-dependent insulinotropic activity of a novel imidazoline compound BL11282

    Författare :Vladimir Sharoyko; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Insulin secretion; pancreatic islets; imidazolines; BL11282; arachidonic acid; phospholipase; cytochrome P-450; GLP-1; desensitization; Rhes;

    Sammanfattning : We developed a novel, pure glucose-dependent, insulinotropic imidazoline compound, BL11282, which directly affects the insulin exocytotic machinery and does not block the KATP channel activity. BL11282 does not induce insulin secretion at basal glucose concentrations, whereas it stimulates insulin secretion at an elevated glucose level. LÄS MER

  4. 24. Modulation by substance P in the lamprey spinal cord

    Författare :Carolina Thörn Pérez; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Neuromodulation is a key element for animal adaptation to environmental circumstances. Neuromodulators can alter the output of a physiological system by acting on the motor circuit by transforming intrinsic firing properties and altering synaptic strength. Substance P belongs to the family of tachykinin, which are peptidergic neuromodulators. LÄS MER

  5. 25. Neural mechanisms for the visual control of spatial orientation and locomotion : electrophysiological and behavioural studies of the supraspinal control of posture and steering in the lamprey central nervous system, with reference to visuo-motor mechanisms

    Författare :Fredrik Ullén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Neural mechanisms for the supraspinal control of posture and steering, in particular visuo-motor control and visuo-vestibular interaction in postural control, were investigated, using the lamprey as a model system. Behavioural experiments on intact and chronically lesioned animals, intra- and extracellular recordings in vitro and retrograde staining of neurons with horseradish peroxidase were utilized. LÄS MER