Sökning: "platelet-derived growth factor receptor"

Visar resultat 6 - 10 av 95 avhandlingar innehållade orden platelet-derived growth factor receptor.

  1. 6. Tissue Factor Biological Functions : Coagulation Activity in Microparticles and Signaling with Focus On Migration and Apoptosis

    Författare :Mikael Åberg; Agneta Siegbahn; Carl-Henrik Heldin; Teet Velling; Björn Dahlbäck; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tissue factor; Apoptosis; Migration; Chemotaxis; Simvastatin; Platelet Derived Growth Factor; Cell Signaling; Microparticles; Prostasomes; Trombosis; Coagulation; Prostate Cancer; Breast Cancer; Caspase-3; Caspase-8; NFkappaB; PAR2; Transactivation; Monocytes; Clinical chemistry; Klinisk kemi;

    Sammanfattning : Background: Tissue factor (TF) is a 47 kDa transmembrane glycoprotein known as the main initiator of blood coagulation. TF is over-expressed on many malignant cells and apart from increasing the risk of thrombosis, the presence of TF/FVIIa also promotes the progression of cancer and metastasis by intracellular signaling. LÄS MER

  3. 7. Signal transduction via the ß-receptor for platelet-derived growth factor

    Författare :Klaus Hansen; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : .... LÄS MER

  4. 8. Regulation of Platelet-Derived Growth Factor Receptor Signaling and its Targeting in Cancer Therapy

    Författare :Haisha Ma; Johan Lennartsson; Håkan Axelson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PDGF; PDGFR; Ras; macropinocytosis; Fer; STAT3; HD-PTP; Cbl; ubiquitination; pericyte; vasculature; tumor; ASKA; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

    Sammanfattning : Overactivity of platelet-derived growth factor receptor (PDGFR) is a frequent event in many types of solid tumors. Therefore, it is of great importance to uncover the mechanisms that regulate PDGF/PDGFR signalling, to develop efficient inhibitors targeting this pathway. LÄS MER

  5. 9. Transcriptional Regulation of the Platelet-Derived Growth Factor B-receptor by p53 Family Members

    Författare :Daniel Wetterskog; Göteborgs universitet; []
    Nyckelord :;

    Sammanfattning : Aims: The platelet-derived growth factor ?-receptor (PDGFRB) is critically involved in embryonic development and has a role in many diseases. In cells, signaling through PDGFRB affects growth, migration and death. LÄS MER

  7. 10. Studies on the tyrosine kinase activity associated with the receptor for platelet-derived growth factor

    Författare :Bo Ek; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : .... LÄS MER